756601
Description
Flashcards by gina_evans0312, updated more than 1 year ago
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Created by gina_evans0312
over 10 years ago
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| Question | Answer |
| Virus Type | Enveloped, with glycoprotein spikes |
| Virus Shape | Icosahedral |
| Primary Infection (Children/Young Adults) | Mild to extensive lesions on the mouth and lips |
| Secondary Infection/Recurrence | Repeated cold sores in the same place |
| Genome | Ds, with both strands coding |
| Genes | 20% unique to HSV1, and created by differential splicing |
| Gene Control/Life Cycle | Have latent & lytic cycles depending on the nuclear environment |
| Location of Replication | Nucleus |
| Productive/Lytic Cycle- Location | Infects host skin cells |
| Lytic Genome Cycle | Alpha-T/F activates early genes in a specific sequence using host polymerase |
| Lytic Cycle- Gene Expression Wave 1 | Alpha, in the 'Early Intermediate' Stage (these genes continue production throughout later stages) |
| Lytic Cycle- Gene Expression Wave 2 | Beta, in the 'Early' Stage (these genes continue production throughout later stages) |
| Lytic Cycle- Gene Expression Wave 3 | Gamma, in the 'Late' Stage |
| Latent Cycle Location | Neurones near initial infection site |
| Latent Cycle Genome | Genome is packaged rapidly in host cell chromatin and silenced |
| No of Origins of Replication | Three (of lytic replication) but only uses one |
| Replication of HSV1- Bases in Origin | Rich in A-T to make replication easier |
| Replication of HSV1- Ori Protein | Ori Binding Protein binds to specific elements for unwinding |
| Replication of HSV1- Helicase Primase | Starts replication before DNA polymerase takes over |
| Replication In Cells | In cells that aren't replicating |
| Replication of HSV1- DNA Length | DNA several genomes long is made, then cut into individual genomes for virions |
| Replication of HSV1- DNA Shape | Initially linear, then becomes circular |
| Assembly | Self folding proteins form capsule, which are then cleaved so DNA can enter |
| Antivirals | Acyclovar |
| Acyclovar Activation | Works by P drug inside viral enzymes, which traps it in cells so cell can add two more P |
| Acyclovar Role | Blocks DNA synthesis, inhibits viral DNA polymerase |
| A1C316 | Inhibit Helicase/Primase Inhibitor that prevents the production of short primers for replication |
| Bicyclic Nucleotide Analogues | Inhibits polymerase in VZV (Chicken pox) |
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