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Cytochrome P450 monooygenases

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Pharmacy Flashcards on Cytochrome P450 monooygenases, created by Katlyn Humrichouse on 15/02/2017.
Katlyn Humrichouse
Flashcards by Katlyn Humrichouse, updated more than 1 year ago
Katlyn Humrichouse
Created by Katlyn Humrichouse almost 8 years ago
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cytochrome P450 monooxygenases
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NADPH: P450 oxidoreductase needed for extra electron flow
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super family: P450 (CYP) monomeric proteins, M=45,000 and 60,000 Da and catalytic iron porphyrin group (heme). activate molecular oxygen and transfer to substrates
heme cofactor connected via a corrdinate bond, Fe is coordianted to 4 nitrogens of protoporphyrin
Image: 401d652e-f8f0-4086-bd54-f4b5f69a62c0 (image/png)
overall reaction
Image: 3dafd726-cb17-47b8-b384-200ff350f9ca (image/png)
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