7857971
Description
Flashcards by Margaret-Estefani Conde Paredes, updated more than 1 year ago
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Created by Margaret-Estefani Conde Paredes
over 7 years ago
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| Question | Answer |
| What are the criteria for a neurotransmitter (NT)? | - presence -stored in vesicles -release -effect -termination of effect |
| What are the characteristics of transmitters in CNS? | -always agonists -can produce fast or slow events -can excite or inhibit -determined by receptors -ion channel-fast-neurotransmission - 2nd messengers-slow-neuromodulation |
| What are the characteristics of receptors? | -determine the effects of transmitters and drugs -excitatory or inhibitory - never both -fast (msecs) or slow (sec to min) effects -subtypes- can result in mixed effects |
| What is the role of pre-synaptic receptors? | Pre-synaptic receptors alter NT release (WHERE THEY CONTROL TRANSMITTER RELEASE) |
| What is the role of post-synaptic receptors? | Post-synaptic receptors alter activity (CONTROLLING NEURONAL FIRING) |
| What are the main types of neurotransmitters and their effects? | *glutamate: major excitatory transmitter *GABA: major INHIBITORY transmitter -Acetylcholine: mixed effects -Noradrenaline: mixed effects -5HT: mixed effects -Dopamine: mixed effects > peptides- substance P (excitatory) -opioids (inhibitory) > nitric oxide: excitatory > adenosine: inhibitory |
| What are the features of glutamate? | * major excitatory transmitter in CNS * most neurones respond to glutamate * often found in long pathways * point to point transmission * can cause long term changes |
| Which four receptors act glutamate on? | 1. AMPA postsynaptic receptor (ionotropic) 2. NMDA postsynaptic receptor (ionotropic) 3. fast presynaptic excitatory KAINATE receptor 4. slow METABOTROPIC receptors (G-proteins) |
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