8934343
Description
Flashcards by Victoria Wright, updated more than 1 year ago
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Created by Victoria Wright
over 7 years ago
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| Question | Answer |
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Endotoxin (lipid A component) |
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Macrophage activation (TLR4) |
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Complement activation |
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Tissue factor activation |
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IL-1, IL-6 |
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TNF-α |
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Nitric oxide |
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C3a |
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C5a |
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Coagulation cascade |
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Fever |
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Fever and Hypotension |
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Hypotension |
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Histamine release: Hypotension and edema |
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Neutrophil chemotaxis |
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DIC |
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| Mnemonic Device To Remember ENDOTOXINS What is E in ENDOTOXINS? | Edema |
| Mnemonic Device To Remember ENDOTOXINS What is the first N in ENDOTOXINS? What is the second? | Nitric oxide Neutrophil chemotaxis |
| Mnemonic Device To Remember ENDOTOXINS What is the D in ENDOTOXINS? | DIC/Death |
| Mnemonic Device To Remember ENDOTOXINS What is the first O in ENDOTOXINS? What is the second? | Outer membrane O-antigen + core polysaccharide + lipid A |
| Mnemonic Device To Remember ENDOTOXINS What is the T in ENDOTOXINS? | TNF-α |
| Mnemonic Device To Remember ENDOTOXINS What is the X in ENDOTOXINS? | eXtremely heat stable |
| Mnemonic Device To Remember ENDOTOXINS What is the I in ENDOTOXINS? | IL-1 and IL-6 |
| Mnemonic Device To Remember ENDOTOXINS What is the S in ENDOTOXINS? | Shock |
| Endotoxins Where is LPS found? In what? | LPS found in outer membrane of gram ⊝ bacteria (both cocci and rods). |
| Endotoxins Composed of what? | Composed of O antigen + core polysaccharide + lipid A (the toxic component). |
| Endotoxins How are they released? | Released upon cell lysis or by living cells by blebs detaching from outer surface membrane (vs exotoxin, which is actively secreted). |
| Endotoxins Three main effects? | Three main effects: macrophage activation (TLR4), complement activation, and tissue factor activation. |
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