Chapter 2 - Structure and Function of Cells of the Nervous System

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Flashcards for Chapter 2 of Foundations of Behavioral Neuroscience
Lorann Kearney
Flashcards by Lorann Kearney, updated more than 1 year ago
Lorann Kearney
Created by Lorann Kearney over 7 years ago
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sensory neuron neuron that detects changes in the external or internal environment and sends information about these changes to the central nervous system
motor neuron neuron located within the central nervous system that controls the contraction of a muscle or the secretion of a gland
interneuron neuron located within the nervous system
Central Nervous System (CNS) the brain and spinal cord
Peripheral Nervous System (PNS) The part of the nervous system outside the brain and spinal cord, including the nerves attached to the brain and spinal cord
soma cell body of a neuron, which contains the nucleus
dendrite a branched, treelike structure attached to the soma of a neuron that receives information from the terminal buttons of other neurons
synapse junction between the terminal button of an axon and the membrane of another neuron
axon the long, thin, cylindrical structure that conveys information from the soma of a neuron to its terminal buttons
multipolar neuron a neuron with one axon and many dendrites attached to its soma
bipolar neuron a neuron with one axon and one dendrite attached to its soma
unipolar neuron a neuron with one axon attached to its soma; the axon divides, with one branch receiving sensory information and the other sending the information into the central nervous system
terminal button the bud at the end of a branch of an axon; forms synapses with another neuron; sends information to that neuron
neurotransmitter a chemical that is released by a terminal button; has a excitatory or inhibitory effect on another neuron
membrane a structure consisting principally of lipid molecules that defines the outer boundaries of a cell and also constitutes many of the cell organelles
cytoplasm the viscous, semiliquid substance contained in the interior of a cell
mitochondria an organelle that is responsible for extracting energy for nutrients
adenosine triphosphate (ATP) a molecule of prime importance to cellular energy metabolism; its breakdown liberates energy
nucleus a structure in the central region of a cell, containing the chromosomes
chromosome a strand of DNA, with associated proteins, found in the nucleus that carries genetic information
deoxyribonucleic acid (DNA) a long, complex macromolecule consisting of two interconnected helical strands; along with associated proteins, strands of DNA constitute the chromosome
gene the functional unit of the chromosome, which directs synthesis of one or more proteins
cytoskeleton support structure formed of microtubules and other protein fibers that are linked to each other and form a cohesive mass that gives a cell its shape
enzyme a molecule that controls a chemical reaction, combining two substances or breaking a substance into two parts
axoplasmic transport an active process by which substances are propelled along microtubules that run the length of the axon
microtubule a long strand of bundles of protein filaments arranged around a hollow core; part of the cytoskeleton and involved in transporting substances from place to place within the cell
glia the supporting cells of the central nervous system
astrocyte a glial cell that provides support for neurons of the central nervous system, provides nutrients and other substances, and regulates the chemical composition of the extracellular fluid
phagocytosis the process by which cells engulf and digest other cells or debris caused by cellular degeneration
oligodendrocyte a type of glial cell in the central nervous system that forms myelin cheaths
myelin sheath a sheath that surrounds axons and insulates them, preventing messages from spreading between adjacent axons
mode of Ranvier a naked portion of a myelinated axon, between adjacent oligodendroglia or Schwann cells
microglia the smallest of glial cells which act as phagocytes and protect the brain from invading microorganisms
Schwann cell a cell in the peripheral nervous system that is wrapped around a myelinated axon, providing one segment of its myelin sheath
blood-brain barrier a semipermeable barrier between the blood and the brain produced by the cells in the walls of the brain's capillaries
area postrema a region of the medulla where the blood-brain barrier is weak; poisons can be detected there and can initiate vomiting
electrode a conductive medium that can be used to apply electrical stimulation or to record electrical potentials
microelectrode a very fine electrode, generally used to record activity of individual neurons
membrane potential the electrical charge across a cell membrane; the difference in electrical potential inside and outside the cell
oscilloscope a laboratory instrument that is capable of displaying a graph of voltage as a function of time on the face of a cathode ray tube
resting potential the membrane potential of a neuron when it is not being altered by excitatory or inhibitory postsynaptic potentials; approximately -70mV in the giant squid axon
depolarization reduction (towards zero) of the membrane potential of a cell from its normal resting potential
hyperpolarization an increase in the membrane potential of a cell, relative to the normal resting potential
action potential the brief electrical impulse that provides the basis for conduction of information along an axon
threshold of excitation the value of the membrane potential that must be reached to produce an action potential
diffusion movement of molecules from regions of high concentration to regions of low concentration
electrolyte an aqueous solution of a material that ionizes - namely, a soluble acid, base, or salt
ion a charged molecule that can be positively (cat-) or negatively (an-) charged
electrostatic pressure the active force between atomic particles charged with opposite signs or the repulsive force between atomic particles charged with the same sign
intracellular fluid the fluid contained within cells
extracellular fluid body fluids located outside of cells
sodium-potassium transport a protein found in the membrane of all cells that extrudes sodium ions from and transports potassium ions into the cell
ion channel a specialized protein molecule that permits specific ions to enter or leave cells
voltage-dependent ion channel an ion channel that opens or closes according to the value of the membrane potential
all-or-none law the principle that once an action potential is triggered in an axon, it is propagated, without decrement, to the end of the fiber
rate law the principle that variations in the intensity of a stimulus or other information being transmitted in an axon are represented by variations in the rate at which that axon fires
saltatory conduction conduction of action potentials by myelinated axons. the action potential appears to jump from one node of Ranvier to the next
postsynaptic potential alterations in the membrane potential of a postsynaptic neuron, produced by liberation of neurotransmitter at the synapse
binding site the location on a receptor protein to which a ligand binds
ligand a chemical that binds with the binding site of a receptor
dendritic spine a small bud on the surface of a dendrite, with which a terminal button of another neuron forms a synapse
presynaptic membrane the membrane of a terminal button that lies adjacent to the postsynaptic membrane and through which the neurotransmitter is released
postsynaptic membrane the cell membrane opposite the terminal button in a synapse; the membrane of the cell that receives the message
synaptic cleft the space between the presynaptic membrane and the postsynaptic membrane
synaptic vescile a small, hollow, beadlike structure found in terminal buttons; contains molecules of a neurotransmitters
release zone a region of the interior of the presynaptic membrane of a synapse to which synaptic vesciles attach and release their neurotransmitters into the synaptic cleft
postsynaptic receptor a receptor molecule in the postsynaptic membrane of a synapse that contains a binding site for a neurotransmitter
neurotransmitter-dependent ion channel an ion channel that opens when a molecule of a neurotransmitter binds with a postsynaptic receptor
ionotropic receptor a receptor that contains a binding site for a neurotransmitter and an ion channel that opens when a molecule of the neurotransmitter attaches to the binding site
metabotropic receptor a receptor that contains a binding site for a neurotransmitter that activates an enzyme that begins a series of events that opens an ion channel elsewhere in the cell's membrane when a molecule of the transmitter attaches to the binding site
G protein a protein coupled to a metabotropic receptor that conveys messages to other molecules when a ligand binds with and activates the receptor
second messenger a chemical produced when a G protein activates an enzyme; carries a signal that results in the opening of the ion channel or causes other events to occur in the cell
excitatory postsynaptic potention (EPSP) an excitatory depolarization of the postsynaptic membrane of a synapse caused by the liberation of a neurotransmitter by the terminal button
inhibitory postsynaptic potential (IPSP) an inhibitory hyperpolarization of the postsynaptic membrane of a synapse caused by the liberation of a neurotransmitter by the terminal button
reuptake the reentry of a neurotransmitter just liberated by a terminal button back through its membrane, thus terminating the postsynaptic potential
enzymatic deactivation the destruction of a neurotransmitter by an enzyme after its release (Example: the destruction of acetylcholine by acetylcholinesterase
acetylcholine (ACh) a neurotransmitter found in the brain, spinal cord, and parts of the peripheral nervous system that is responsible for muscular contraction
acetylcholinestrase (AChE) The enzyme that destroys acetylcholine soon after it is liberated by the terminal buttons, thus terminating the postsynaptic potential
neural integration the process by which inhibitory and excitatory postsynaptic potentials summate and control the rate of firing of a neuron
autoreceptor a receptor molecule located on a neuron that responds to the neurotransmitter released by that neuron
presynaptic inhibition the action of a presynaptic terminal button in an axoaxonic synapse that reduces the amount of neurotransmitter released by the postsynaptic terminal button
presynaptic facilitation the action of a presynaptic terminal button in an axoaxonic synapse that increases the amount of neurotransmitter released by the postsynaptic terminal button
neuromodulator a naturally secreted substance that acts like a neurotransmitter except that it is not restricted to the synaptic cleft but diffuses through the extracellular fluid
peptide a chain of amino acids joined together by peptide bonds. Most neuromodulators, and some hormones, consist of these molecules
hormone a chemical substance that is released by an endocrine gland and that has effects on target cells in other organs
endocrine gland a gland that liberates its secretions into the extracellular fluid around capillaries and hence into the bloodstream
target cells the type of cell that contains receptors for a particular hormone and is affected by the hormone
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