950499
Description
Flashcards by savaniprachi, updated more than 1 year ago
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Created by savaniprachi
over 10 years ago
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| Question | Answer |
| The structure of the ER | Dynamic network-continually breaking and reforming. Connected to the nuclear envelope. Forms hollow tubes and flattened sacs. Chambers are called cisternae. RER(ribosomes) and SER(no ribosomes) |
| Major functions of the ER | 1. Synthesis 2. Storage 3. Transport 4. Detoxification |
| Functions of the SER | 1. Phospholipid and cholesterol synthesis 2. Steroid hormone production 3. Synthesis and storage of glycerides 4. Synthesis and storage of glycogen 5. Important role as calcium store |
| Detoxification in the SER | By the p450 cytochrome family: Break down of medications and toxins Involved in the synthesis of things such as steroid hormones Changes water insoluble drugs to soluble so they can be removed in urine |
| The structure of the Golgi Apparatus | Flattened discs called cisternae has 5-6 cisternae near nucleus Communicates with ER and plasma membrane by vesicles |
| Functions of the Golgi Apparatus | 1. Modifies and packages secretory proteins for release (exocytosis) 2. Renews and modifies the cell membrane 3. Delivery of material to other organelles |
| What is the site of Carbohydrate production? | Golgi Apparatus |
| What do vesicle coats do? | Aid in formation of the vesicle |
| What are the 3 types of coats and their involvement in specific transport? | COPII - vesicles from ER to Golgi COPI - vesicles coming backwards from Golgi to ER Clathrin - endocytosis cell membrane to Golgi |
| What is the use of SNAREs? | To help vesicles reach the correct targets |
| Where can you find the SNAREs? | v-SNARE on the vesicle membrane t-SNARE on the target membrane |
| What are the 2 models for progression through the Golgi and how do they differ? | Vesicular transport model - static where vesicles move from one cisternae to another Cisternae maturation model - dynamic where the cis may become trans |
| 3 pathways from the trans-golgi network | 1. Regulated secretory pathway - exocytosis 2. Constitutive secretory pathway - membrane proteins 3. Signal mediated diversion to lysosomes |
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