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2850562
OXAZOLIDINONAS.
Description
Mind Map on OXAZOLIDINONAS., created by Juliana Diaz Mey on 30/05/2015.
Mind Map by
Juliana Diaz Mey
, updated more than 1 year ago
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Created by
Juliana Diaz Mey
over 9 years ago
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Resource summary
OXAZOLIDINONAS.
LINEZOLID
MECANISMO DE ACCIÓN
Inhibe síntesis de proteínas bacterianas por unión a la subunidad 50S
FARMACOCINÉTICA
La biodisponibilidad oral de linezolid es 100%
La unión a proteínas es baja
Se metaboliza a tráves de oxidación, originando dos metabolitos inactivos.
Su vida media es de 4 a horas
FARMACODINAMIA
agente antibacteriano sintético
Aumenta efecto hipertensivo de: pseudoefedrina, fenilpropanolamina
USOS CLÍNICOS
Infecciones causadas por bacterias grampositivas resistentes
Infecciones por E.faecium, neumonía nosocomial, neumonía adquirida en la comunidad.
PRESENTACIÓN
Tabletas de 400 y 600 mg, sln inyectable 2mg/ml
Dosis:
Adultos: 600 mg cada 12 horas por 10 días
RAMS
Trombocitopenia, vómitos, diarrea,cefalea
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