Dysbiosis is the shift in balance of normal microflora (type and quantity, metabolic activity and distribution) in the large intestine, resulting in a microbata which produces harmful effects
Small intestine bacterial
overgrowth (SIBO)
Causes
Stress
Poor diet
Decreased digestive secretions
Antibiotics
Excessive alcohol
Altered bowel motility
Immune suppression
Symptoms
Local symptoms
Indigestion
bloating
nausea
diarrhea/constipation
Associated with diseases
Immune disregulation
inflammation
metabolic disturbances
Systemic
Autoimmune
Rheumatoid arthritis
Ankalising spondilitis
Allergies
UTI's
Thrush
GIT
Irritable bowel syndrome
inflammatory bowel disease
enteric infections
Leads to:
Increased intestinal permeability, pathogens adhere to epithelial lining and damage tight junctions
Inflammation: pathogens induce epithelial cells to secrete inflammatory cytokines,
adhesion molecules, and major hitocompatibility complex class II molecules, stimulates
immune cells eg neutrophils, monocytes, lymphocytes and eosinophils