1032183
Description
Mind Map by sesamemonstersx, updated more than 1 year ago
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Created by sesamemonstersx
over 10 years ago
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Pharmacological Treatments
for DYSPEPSIA, GASTRITIS &
PEPTIC ULCER
- Acid Suppression
- Histamine (H2) Receptor antagonist
- MOA: Inhibits the action of Histamine ay H2
receptor on Parietal Cells
- Administration
- Twice Daily
- Single dose at night for
4-8 weeks
- Twice Daily
- Side effects
- Diarrhoea
- Altered Liver
Function Test
- Headache
- Dizziness
- Rash
- Tiredness
- Diarrhoea
- MOA: Inhibits the action of Histamine ay H2
receptor on Parietal Cells
- Proton Pump Inhibitor
- MOA: Inhibit H+/K+ dependent
ATPasse proton pump, degreasing
gastric acid secretion
- Better than H2 antagonist as H2 only
inhibit Histamine component, PPI inhibit
the proton Pump
- Better than H2 antagonist as H2 only
inhibit Histamine component, PPI inhibit
the proton Pump
- Examples
- Omepraozole
- Esomeprazole
- Omepraozole
- Side Effects
- GI distrbances
- Headache
- DIzziness
- GI distrbances
- Caution
- Gastric Cancer
- Liver disease
- Pregnancy & breast
feeding
- Gastric Cancer
- MOA: Inhibit H+/K+ dependent
ATPasse proton pump, degreasing
gastric acid secretion
- Histamine (H2) Receptor antagonist
- Antacids
- Types
- Magnesium
- Diarrhoea
- Diarrhoea
- Aluminium
- Contipation
- Contipation
- Calcium
- Hypercalcemia
- Hypercalcemia
- Magnesium
- MOA: Neutralize Gastric Activity
- Increase In stomach
and duodenal pH
- Inactivation of pepsin
- Increase In stomach
and duodenal pH
- Alginate-containing
- Forms a raft that floats on the
surface of the stomach content
- Forms a raft that floats on the
surface of the stomach content
- Types
- Prokinetics
- MOA: Dopamine antagonist
- Stimulate gastric emptyping &
small intestinal transit
- Enhance strength of
esophageal spinchter
contration
- Stimulate gastric emptyping &
small intestinal transit
- Examples
- Metoclopramide
- Doperidone
- Metoclopramide
- Side Effects
- High blood
prolactin level
- Enlargement of breast in male
- Abnormal production of
breast milk
- High blood
prolactin level
- MOA: Dopamine antagonist
- Cytoprotectives
- Chelates
- Unknown MOA
- Examples
- Tripotassium
Dicitratobismuthate
- Rinitidine bismuth
citrate
- Tripotassium
Dicitratobismuthate
- Unknown MOA
- Misoprostol
- Uses
- Older Frail People
- prevention of gastric ulcer in
patients requiring long tern
non-steroidal or aspirin therapy
- Older Frail People
- MOA: Antisecretory,
inhibit basal & noctonal
gasric acid secretion by
parietal cells
- Uses
- Complexes
- Sucralfate
- MOA: activated by acid, forms
viscous adherent gel that bind to
ulcer crater
- inhibit pepsin, absorbs bile salts
- inhibit pepsin, absorbs bile salts
- MOA: activated by acid, forms
viscous adherent gel that bind to
ulcer crater
- Side effects
- Constipation,
diarrhoea
- Nausea
- Gastric Discomfort
- Constipation,
diarrhoea
- Sucralfate
- Chelates
- H.pylori Eradication
- Recommended regimen
- Recommended regimen
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