Enzyme-linked cell surface receptors

Definition
1. Transmembrane proteins
2. Extracellular ligand binding domain
3. Cytosolic domain has intrinsic enzymatic activity or associates with an enzyme
4. Each subunit has 1 TM domain
5. Often activates same signalling pathways as GPCR
At least 5 classes
1. Receptor tyrosine kinases
2. Tyrosine-kinase associated receptors
3. Receptor-like tyrosine phosphatases
4. Receptor serine/threonine kinases
5. Receptor guanylyl cyclases
Receptor tyrosine kinases
1. What domains bind phosphorylated tyrosine residues?
  1. SH2 domains
  2. Modular binding domains
2. Activate Ras-mediated protein kinase signalling
Tyrosine-kinase associated receptors
Receptor-like tyrosine phosphatases
Receptor serine/threonine kinases
Receptor guanylyl cyclases
1. Single pass transmembrane protein with extracellular ligand binding site
2. Intracellular guanylyl cyclase domain catalyses cyclic GMP formation
  1. cGMP binds and activates cyclic GMP-dependent protein kinase (PKG) or ion channels
3. Signal molecules
  1. Natriuretic peptides (NP's)
    1. Regulate salt and water balance and dilate blood vessels
    2. E.g.
      1. Atrial natriuretic peptide (ANP)
      2. Brain natriuretic peptide (BNP)
    3. Involved in diseases such as hypertension

Resource summary

	Created by Kristi Brogden over 11 years ago