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Enzyme-linked cell surface receptors

Description

Undergraduate BMS238 Cell and molecular biology Mind Map on Enzyme-linked cell surface receptors, created by Kristi Brogden on 17/08/2014.
Kristi Brogden
Mind Map by Kristi Brogden, updated more than 1 year ago
Kristi Brogden
Created by Kristi Brogden over 10 years ago
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Resource summary

Enzyme-linked cell surface receptors
  1. Definition
    1. Transmembrane proteins
      1. Extracellular ligand binding domain
        1. Cytosolic domain has intrinsic enzymatic activity or associates with an enzyme
          1. Each subunit has 1 TM domain
            1. Often activates same signalling pathways as GPCR
            2. At least 5 classes
              1. Receptor tyrosine kinases
                1. Tyrosine-kinase associated receptors
                  1. Receptor-like tyrosine phosphatases
                    1. Receptor serine/threonine kinases
                      1. Receptor guanylyl cyclases
                      2. Receptor tyrosine kinases
                        1. What domains bind phosphorylated tyrosine residues?
                          1. SH2 domains
                            1. Modular binding domains
                            2. Activate Ras-mediated protein kinase signalling
                            3. Tyrosine-kinase associated receptors
                              1. Receptor-like tyrosine phosphatases
                                1. Receptor serine/threonine kinases
                                  1. Receptor guanylyl cyclases
                                    1. Single pass transmembrane protein with extracellular ligand binding site
                                      1. Intracellular guanylyl cyclase domain catalyses cyclic GMP formation
                                        1. cGMP binds and activates cyclic GMP-dependent protein kinase (PKG) or ion channels
                                        2. Signal molecules
                                          1. Natriuretic peptides (NP's)
                                            1. Regulate salt and water balance and dilate blood vessels
                                              1. E.g.
                                                1. Atrial natriuretic peptide (ANP)
                                                  1. Brain natriuretic peptide (BNP)
                                                  2. Involved in diseases such as hypertension
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