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11607779
Respiratory Drugs
Description
Pharmacology 214.202 Massey university NZ
Mind Map by
Samara Watts
, updated more than 1 year ago
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Created by
Samara Watts
almost 7 years ago
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Resource summary
Respiratory Drugs
Bronchodilators
B2 adrenergic agonists
Short acting
Salbutamol, terbutaline
used for actue asthma
Long acting
eformoterol, salmeterol
used as a symptom controller
MOA: Stimulate B2 adrenergic receptors on the bronchial smooth muscles and stimulates sympathetic nervous system response - causing bronchodilation.
Adverse effects: tremors, tachycardia, headache, increased blood glucose levels,
Antimuscarinics
Short acting
Ipratropium
Long acting
tiotropium, glycopyrronium
Theraputic action: bronchodilation, decreased mucous secretion action
MOA: block muscarinic receptors and inhibit the parasympathetic nervous system
Adverse reactions: dry mouth/throat irritation, blurred vision.
Methylxanthines
Theophylline, aminophylline
Theraputic action: increased cellular activity and bronchodilation
MOA: inhibits the enzyme that degrades cAMP
Adverse reactions: insomnia, anxiety, tremors, tachycardia, nausea
Preventer drug
Leukotriene receptor antagonists
Montelukast
Theraputic Action: mediate inflammatory reactions
MOA: blocks action of inflammation mediators
Adverse effects: headache, GI upset, thirst
Mast cell stabilisers
Sodium cromoglycale
Theraputic action: preventer group
MOA: prevents release of inflammatory mediators from mast cells
Adverse effects: Throat irritation, nausea
Steriods
Steroidal Anti-iinflammatory
Systemic corticosteriods
Prednisone, Methylprednisolone
Inhaled corticosteriods
Beclometasone, Fluticasone
Theraputic Action: bronchoconstriction and inflammation decreation
MOA: inhibits rupture of mast cells, decreases inflammatory mediators, suppresses antibody production and immune cells.
Adverse reactions: Fluid and electrolyte imbalance, immunosuppressence
Combined formulations
Seretide & Symbicort
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