12208000
Description
Mind Map by yousaf alabrash, updated more than 1 year ago
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Created by yousaf alabrash
almost 7 years ago
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Celiac Disease
- malabsorption due to destruction of the villi
- histology: normal villi of the small intestine
- histology: villous destruction in celiac disease
- normal physiology
- digestion: breaking down food into basic components
- carbs
- monosaccarides
- polysaccarides
- Disaccarides
- Disaccarides
- monosaccarides
- proteins
- amino acids
- peptides
- amino acids
- lipids
- fatty acids
- phospholipids
- cholesterol
- cholesterol
- phospholipids
- fatty acids
- absorption: moving the nutrients into the blood
- Glucose in lumen
- SGLT on apical membrane
- Glucose intracellular
- GLUT-2 on basolateral
membrane
- Glucose in blood
- Glucose in blood
- GLUT-2 on basolateral
membrane
- Glucose intracellular
- SGLT on apical membrane
- fats
- diffuse readily!!
- then recycled
- fatty acids
- triglycerides
- triglycerides
- fatty acids
- then recycled
- diffuse readily!!
- amino acids
- Na - amino
acids
cotransporter
- Na - amino
acids
cotransporter
- Glucose in lumen
- carbs
- digestion: breaking down food into basic components
- histology: villous destruction in celiac disease
- pathophysiology
- YOU MUST HAVE TWO THINGS
- ingestion of gluten
- Gluten breaks down into Gliadin
- Gliaden is absorbed and
deaminated by transglutaminase
- APC will present it to T-helper cells
- T cell releases IFN-Y and IL-21
- IL-21
- cause IL-17 release
- and activate B cells
- secrete autoantibodies
- transglutaminase
- endomysium
- Gliaden
- transglutaminase
- secrete autoantibodies
- cause IL-17 release
- IL-21
- T cell releases IFN-Y and IL-21
- epithelial cells express MICA
- IEL expressing NKGD2 binds to MICA
- destruction of the epithelial cells
- ALSO
- epithelial cells releases IL-15
- Inhibits Treg
- development of T cell Lympthoma
- Inhibits Treg
- epithelial cells releases IL-15
- ALSO
- destruction of the epithelial cells
- IEL expressing NKGD2 binds to MICA
- APC will present it to T-helper cells
- Gliaden is absorbed and
deaminated by transglutaminase
- HLA-DQ2 OR HLA-DQ8
- ingestion of gluten
- YOU MUST HAVE TWO THINGS
- normal anatomy of small intestine
- destruction of the villi
- treatment of celiac disease
- Gluten-Free diet!!!
- treatment of Diarrhea
- Antidiarrheal drugs
- Opoids
- codeine
- Diphenoxylate
- Loperamide
- Loperamide
- Diphenoxylate
- codeine
- anticholinergic
- Atropine
- Scopolamine
- Propantheline
- Propantheline
- Scopolamine
- Atropine
- Adsorbents
- Kaolin
- Pectin
- Dietary Fiber
- Dietary Fiber
- Pectin
- Kaolin
- Opoids
- Antidiarrheal drugs
- treatment of Diarrhea
- Gluten-Free diet!!!
- treatment of celiac disease
- signs and symptoms
- bloating
- Diarrhea
- weight loss
- failure to thrive
- malabsorbtion
- bloating
- destruction of the villi
- histology: normal villi of the small intestine
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