12745357
Pancreatitis
- Causes of Acute Abdomen
- Perforating Gastric/Duodenal Ulcer
- Intestinal Obstruction
- Ischemic bowel disease
- Acute Appendicitis
- Acute Cholecystitis & Gallstones
- Acute Pancreatitis
- Peritonitis
- Aortic Dissection
- Ectopic Pregnancy
- Perforating Gastric/Duodenal Ulcer
- Anatomy of the pancreas
- Histology
- Acute
- Clinical findings
- Mid epigastric pain
radiating to the
back
- Pain elevated when leaning forward
- Pain elevated when leaning forward
- Acute abdomen
- Fever
- Nausea and vomiting
- Hypovolemic shock
- Grey turner sign
- Cullen's sign
- Mid epigastric pain
radiating to the
back
- Pathogenesis
- It is mainly caused by alcohol and gall stones
- Must be activation of proenzymes
- Mechanism of activation
- Obstruction of the main pancreatic duct or terminal CBD
- Alcohol
- gallstones
- Alcohol
- Chemical injury of
acinar cells
- Ex: Thiazide
- Ex: Thiazide
- Infectious injury of acinar cells
- CMV
- Mumps
- CMV
- mechanical injury to acinar cells
- trauma
- trauma
- metabolic activation of the enzymes
- hypercalcemia
- ischemia
- shock
- Trypsin activates
- proteases
- damage acinar cell structure
- damage acinar cell structure
- lipases
- produce fat necrosis
- produce fat necrosis
- elastases
- damage blood
vessels and cause
hemorrhage
- damage blood
vessels and cause
hemorrhage
- proteases
- hypercalcemia
- Obstruction of the main pancreatic duct or terminal CBD
- Mechanism of activation
- It is mainly caused by alcohol and gall stones
- Clinical findings
- Chronic
- clinical findings
- Sever pain radiating to the back
- Type 1 diabetes Mellitus
- Malabsorption
- Sever pain radiating to the back
- Pathogenesis
- Majority are idiopathic
- Known causes
- Alcohol
- Cystic fibrosis
- Malnutrition
- Autoimmune
- Alcohol
- Repeted attacks of acute
pancreatitis produce duct
obstruction
- Calcified concentrations
occur as well as dilation of
the duct
- Calcified concentrations
occur as well as dilation of
the duct
- Majority are idiopathic
- happens in
males more than
females
- clinical findings
- Investigation
- Blood tests
- Amylase
- Lipase
- Glycoprotein 2
- Amylase
- Imagining Studies
- Abdominal ultrasound
- Endoscopic ultrasound
- Computed tomography of abdomen with contrast
- MRCP
- ERCP
- Abdominal ultrasound
- Tests for Severity and Prognosis
- C-reactive protein (CRP) 48 hours after symptom onset
- liver function tests
- Calcium
- CBC
- Blood urea nitrogen (BUN)
- C-reactive protein (CRP) 48 hours after symptom onset
- Glasgow criteria
- Blood tests
- Complications
- Shock
- ARDS
- DIC
- Pancreatic pseudocyst
- Pancreatic abcess
- Infections
- Shock
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