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Diabetic nephropathy

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Mind Map on Diabetic nephropathy, created by Nadeen Adi on 18/03/2018.
Nadeen Adi
Mind Map by Nadeen Adi, updated more than 1 year ago
Nadeen Adi
Created by Nadeen Adi over 6 years ago
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Resource summary

Diabetic nephropathy
  1. Anatomy of the kidney
            1. Blood supply
            2. Histology of the kidney
                2. Physiology of glomerular filtration
                    1. Clearance
                      1. Volume of plasma cleared of the substance by the kidney in one minute
                        1. C ml/min (Clearance) = U x V / P
                        2. Glomerular filtration rate
                          1. the clearance of a substance freely filtered at the glomerulus but not reabsorbed or secreted in the tubules
                          3. Pathological features and types of glomerular diseases
                            1. Nephritic syndrome
                              1. Post streptococcal GN
                                1. Rapidly progressive GN (crescentic)
                                  1. IgA nephropathy
                                    1. SLE
                                      1. Alport syndrome
                                      2. Nephrotic syndrome
                                        1. Primary
                                            2. Secondary
                                              1. SLE
                                                1. Diabetes
                                                  1. Pathogenesis
                                                    1. 1. High serum glucose levels lead to hyaline arteriolosclerosis in efferent arteriole
                                                      1. 2. high GFR and microalbuminuria
                                                        1. 3. progress to sclerosis of the mesangium of the glomerulus and nephrotic syndrome
                                                  2. Amyloidosis
                                              2. Complications
                                                1. hypertention
                                                  1. Acute kidney failure
                                                    1. Chronic kidney failure
                                                    2. Renal function tests
                                                      1. Serum Blood Urea Nitrogen (BUN) – 7-18 mg/dL
                                                        1. Serum Creatinine – 0.6-1.2 mg/dL
                                                          1. Serum BUN/Creatinine ratio - 15
                                                            1. Creatinine Clearance (CCr) – 97-137 mL/minute
                                                              1. Urinalysis
                                                              2. Treatment
                                                                1. Diuretics
                                                                  1. Thiazide diuretics
                                                                    1. Loop diuretics
                                                                      1. Potassium sparing diuretics
                                                                        1. carbonic anhydrase inhibitors
                                                                          1. Osmotic diuretics
                                                                          2. Kidney transplantation

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