Multiple sclerosis

Annotations:

• MS is a complex auto‐immune based progressive  neurological disorder with both inflammatory AND  neurodegenerative pathologies

1. Demyelination

   Annotations:

   • Diseases relapse: The T-cells attack the myelin sheets of the Axons.  Deseases  
   1. T-cells
2. axon destruction
   1. Axonal transection
      1. MS lesions

         Annotations:

         • Lesions are not necessary 1:1, it means that not always a damage at X area of the brain will cause an effect due to the plasticity of your brains 
         1. cognitive reserve

1. 20 to early 30s
2. prevalent females
3. distante from the ecuador line

   Annotations:

   • if a person moves from one area to another before their 15's they assume the risk of that area

1. immunological
2. environmental
3. infectious
   1. Epstein-barr
4. genetic
   1. vikings Disease
   2. sibling
5. smoking

1. EDSS

   Annotations:

   • no cognitive criteria :(
2. McDonald Criteria
3. Relapse

   Annotations:

   • Exacerbation, bout, attack, flare-up or episode
   1. fatigue
   2. balance
   3. eyesight
      1. optic neuritis
         1. organising visual info
            1. seeing relationships between objects
   4. bladder
   5. memory & thinking
4. social cognition

   Annotations:

   • critical periodeof 30min after the information was processed 
   1. pseudobular affect
   2. emotion recognition

      Annotations:

      • impaired fear and anger
   3. theory of mind

      Annotations:

      • ability to see another's perspective
   4. inappropriate behavior
   5. depression
   6. fatigue

1. Processing Speed

   Annotations:

   • Affects important things like executive function, memory, due to loss of myelin
2. attention
3. working memory

   Annotations:

   • be able to manipulate and maintain information in the mind .   relax/remining is less likely to have difficulties  Secondary is the most likely  
   1. prospective memory
      1. long-term memory
4. executive abilities
   1. disorganisation
      1. problem solving
         1. sticky thinking
5. depression
   1. fatigue
      1. anxiety

1. Female
2. most aggressive
3. male
4. beginning states