1618557
Description
Mind Map by Kristi Brogden, updated more than 1 year ago
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Created by Kristi Brogden
about 10 years ago
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Recent
developments
in GPCR
signalling
- Signalling pathway
activated by a receptor in
a cell is context specific
- In different cells in the body or in
the same cell at different times,
different things are happening
- Results in greater control
over physiological outcome
- In different cells in the body or in
the same cell at different times,
different things are happening
- Specific signalling
is regulated by
- Adaptor
proteins
- Scaffold
proteins
- Play an important role in bringing
receptors together with certain
pathways
- Play an important role in bringing
receptors together with certain
pathways
- Lipids
(Association
with rafts/lipid
microdomains)
- Endocytosis
- Splicing
- Post-translational
modifications
- Adaptor
proteins
- Regulation through
interacting proteins
- RAMPS
- GRKs
- 7 types
- 7 types
- B-arrestins
- 4 types
- 4 types
- RGS
proteins
- RAMPS
- Therapeutic potential of
agonist-biased signalling
- Does μ-opioid receptor (MOR)
desensitization and trafficking
have any role in tolerance?
- Does μ-opioid receptor (MOR)
desensitization and trafficking
have any role in tolerance?
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