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16364888
Cushing Syndrome
Description
Cushing Syndrome: Causes, Investigations and Management!
No tags specified
cushing's
cortisol
acth
Mind Map by
Aliaa Soliman
, updated more than 1 year ago
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Created by
Beoluf Jangan
almost 7 years ago
Copied by
Yaman Issa
almost 6 years ago
Copied by
Aliaa Soliman
almost 6 years ago
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Resource summary
Cushing Syndrome
Causes
ACTH
Pituitary Dependent
Cushing's Disease
ACTH Administration
Ectopic ACTH secreting Tumour
Impaired GTT (Frank DM)
HypoKalaemia
NON- ACTH
Adrenal
Carcinoma
Adenoma
Alcohol Induced "Psuedo-Cushing's"
Cushingoid Appearance due to alcohol consumption
Glucocorticoid administration
Excess corticoid secretion from adrenal glands
Normal histology
Diagnosis
Differential of Cause
ACTH Dependent
Ectopic
Annotations:
Other tests. Radio-labelled otreotide to locate ectopic ACTH
Plasma ACTH >200ng/L
Frank Diabetes
Hypokalaemia
48 Hr Dexamethasone Test (High Dose)
Failure of Significant Cortisol Suppression.
Chest X-Ray
Bronchial Carcinoid
CT-Lung, Mediastinum and Abdomen
MRI/CT Scan
Bilateral Adrenal Hyperplasia
Pituitary
Annotations:
Other Tests Catheterization of inferior petrosal sinus to measure ACTH for pituitary lesions.
Adenoma
MRI/CT Scan
Cushing Disease
CRH Test
Annotations:
In response to exogenous CRH, Exaggerated ACTH and Cortisol Response is soon.
NON-ACTH
Adrenal
CT/MRI Scan
Tumour
48 Hr Dexamethasone Test (High Dose)
Failure of Significant Cortisol Suppression.
Adenoma
Nodular Hyperplasia
Complications
Osteoporosis
Hypertension
Type 2 diabetes
Loss of muscle mass
Synthesis of adrenocortical hormones
Signs and Symptoms
Treatment
Adrenalectomy
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