Cushing Syndrome

Description

Cushing Syndrome: Causes, Investigations and Management!
Aliaa Soliman
Mind Map by Aliaa Soliman, updated more than 1 year ago More Less
Beoluf Jangan
Created by Beoluf Jangan almost 7 years ago
Yaman Issa
Copied by Yaman Issa almost 6 years ago
Aliaa Soliman
Copied by Aliaa Soliman almost 6 years ago
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Resource summary

Cushing Syndrome
  1. Causes
    1. ACTH
      1. Pituitary Dependent
        1. Cushing's Disease
        2. ACTH Administration
          1. Ectopic ACTH secreting Tumour
            1. Impaired GTT (Frank DM)
              1. HypoKalaemia
            2. NON- ACTH
              1. Adrenal
                1. Carcinoma
                  1. Adenoma
                  2. Alcohol Induced "Psuedo-Cushing's"
                    1. Cushingoid Appearance due to alcohol consumption
                    2. Glucocorticoid administration
                  3. Excess corticoid secretion from adrenal glands
                    1. Normal histology
                    2. Diagnosis
                      1. Differential of Cause
                        1. ACTH Dependent
                          1. Ectopic

                            Annotations:

                            • Other tests. Radio-labelled otreotide to locate ectopic ACTH
                            1. Plasma ACTH >200ng/L
                              1. Frank Diabetes
                                1. Hypokalaemia
                                  1. 48 Hr Dexamethasone Test (High Dose)
                                    1. Failure of Significant Cortisol Suppression.
                                    2. Chest X-Ray
                                      1. Bronchial Carcinoid
                                        1. CT-Lung, Mediastinum and Abdomen
                                    3. MRI/CT Scan
                                      1. Bilateral Adrenal Hyperplasia
                                      2. Pituitary

                                        Annotations:

                                        • Other Tests Catheterization of inferior petrosal sinus to measure ACTH for pituitary lesions.  
                                        1. Adenoma
                                          1. MRI/CT Scan
                                          2. Cushing Disease
                                            1. CRH Test

                                              Annotations:

                                              • In response to exogenous CRH, Exaggerated ACTH and Cortisol Response is soon. 
                                        2. NON-ACTH
                                          1. Adrenal
                                            1. CT/MRI Scan
                                              1. Tumour
                                                1. 48 Hr Dexamethasone Test (High Dose)
                                                  1. Failure of Significant Cortisol Suppression.
                                                2. Adenoma
                                                  1. Nodular Hyperplasia
                                          2. Complications
                                            1. Osteoporosis
                                              1. Hypertension
                                                1. Type 2 diabetes
                                                  1. Loss of muscle mass
                                                  2. Synthesis of adrenocortical hormones
                                                    1. Signs and Symptoms
                                                      1. Treatment
                                                        1. Adrenalectomy
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