a condition in which there is a deficiency
of red cells or of haemoglobin in the blood,
resulting in pallor and weariness.
Insufficient oxygen transport
Tissue hypoxia
Brain
somnolence
and fatigue
Heart
Angina
heart attack
Lung
Dyspnea
and low
respiratory
reserve
Skeletal muscles
Weakness and fatigue
patients's complaint
Progressive tiredness
and fatigue, Shortness of
breath on exertion, Lost
appetite and weight,
Variation in bowel
movements, Abdominal
discomfort, and Dyspepsia
Blood investigations
Showing signs of iron deficiency
anemia and inflammation
Stool Analysis
Positive for occult blood
Divecular bleeding
Diverticular Disease
Crohn’s disease
Colorectal cancer
Pathophysiology
APC/K-RAS/P53 mutations
microsatellite instability
Risk Factors
Increased age
Male gender
Low Socioeconomic status
Black race
Obesity
Types
One sided in the
right side
Annular
growth on the
left side
Management
Stage A - surgical removal
Stage B - surgical resection + adjuvant chemotherapy
Stage C - surgical resection + 5-fluorouracil + Leucovorin
Satge D
Single agent
Fluorouracil
Oxaliplatin
Irinotecan
Combination
Fluorouracil + Irinotecan + Leucovorin
Fluorouracil + Oxaliplatin + Leucovorin
Diffrential diagnosis
IBS
Causes
Gut-brain axis problems
Small intestinal bacterial overgrowth
Genetic factors
Food sensitivity
Gut motility problems
Symptoms
Abdominal discomfort/pain/bloating
Alteration of bowel habits
Risk factors
Physical and sexual abuse
<50 yrs of age
female sex
previous enteric infection
Treatment
treatment of symptoms and in case of association of short
chain carbohydrates then diet management