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17424973
A 62-YEAR-OLD MALE WITH SWELLING IN NECK
Description
Mind Map on A 62-YEAR-OLD MALE WITH SWELLING IN NECK, created by Zainab Kamal on 24/03/2019.
Mind Map by
Zainab Kamal
, updated more than 1 year ago
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Created by
Zainab Kamal
over 5 years ago
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Resource summary
A 62-YEAR-OLD MALE WITH SWELLING IN NECK
Rt.sided neck swelling
noted it after sore throat & was prescribed antibiotics
felt small swelling in Lt. inguinal region, dropped around 7-8kg
cervical lymph node biopsy were ordered.
sections show diffuse effacement of lymph node architecture by large lymphoid cells
diagnosis: Non-Hodgkin lymphoma
confirmed the final diagnosis of Diffuse Large B cell NHL
immunohistochemistry: +ve for CD19, CD20, and CD45 and -ve for CD5, CD3. Variable expression of CD10 and BCL6 was noted.
CT: Rt. cervical & Lt. inguinal with diffuse involvement of retroperitoneal nodes, high LDH
stage IIIB Diffuse large B cell Non-Hodgkin lymphoma.
treated with six cycles of rituximab + CHOP chemotherapy
R-CHOP
R-CVP
FCR
DA-EPOCH
low
small lymphocytes, flollicular
intermediate
diffuse small, diffuse large, diffue mixed
high
large cell, immunoblastic, lymphoblastic
miscellaneous
diagnosis
biopsy
Contrast CT
X-ray
PET
CBC
immunohistochemstry
flow cytometry
B cell lymphoma
CD19, CD20
T cell lymphoma
CD3, CD4, CD8
hodgkin
reed stirnberg cells
Ass. EBV
localized, single
non hodgkin
multiple, spread
majority B cells
Ass. HIV
Core needle biopsy
Fine needle aspiration
Excisional biopsy
permits the hematopathologist to evaluate the architecture of the lymph node.
signs & symptoms
swollen lymph nodes
Abdominal pain
Night sweats
weight loss
risk factors
low immunity
infections
HIV
EBV
H.pyori
HCV
HTLV-1
age above 60
lymph node distribution
Media attachments
1f5e08a6793a99aa1b639236de403007 (binary/octet-stream)
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