17884589
Description
Mind Map by Hyatt Alraeesi, updated more than 1 year ago
|
Created by Hyatt Alraeesi
over 5 years ago
|
|
Muhammed’s
Spleen is
Palpable
- Epidemiology
- BY RACE & ETHNICITY
- White people
- White people
- BY AGE GROUP
- 65-74
- 65-74
- % surviving 5 years
- 61.4%
- 61.4%
- BY RACE & ETHNICITY
- Leukocytosis Vs Leukemia
- both have High WBC count
- Leukemia
- Caused by
genetic
mutations
- More severe
- WBCs
don’t
function
properly
- WBCs
don’t
function
properly
- Always
pathological
- Caused by
genetic
mutations
- Leukocytosis
- Caused
by
infections
- pathological
or
physiological
effects
- Less severe
- WBCs
function
normally
- WBCs
function
normally
- Caused
by
infections
- Leukemia
- both have High WBC count
- pharmacology
- Imatinib
- Action
- inihibiting tyrosine kinase enzyme
- inihibiting tyrosine kinase enzyme
- Side effects
- nausea/vomiting/diarrhea
- edema/skin rash
- edema/skin rash
- nausea/vomiting/diarrhea
- Administration
- given orally and metabolized by CYP3A4
- given orally and metabolized by CYP3A4
- Action
- Dasatinib & Nilotinib
- Administration
- orally
- orally
- Action
- inihibiting
tyrosine kinase
enzyme
- inihibiting
tyrosine kinase
enzyme
- Used in
- ALL
- CML
- ALL
- Administration
- Imatinib
- high WBC count
over 11,000
cells/mm3
- Only one type of WBC is
affected
- Basophils
- may occur in people with a history of underactive thyroid disease,
known as hypothyroidism.
- may occur in people with a history of underactive thyroid disease,
known as hypothyroidism.
- Monocytes
- indicate the presence of chronic infection, an
autoimmune or blood disorder, cancer.
- indicate the presence of chronic infection, an
autoimmune or blood disorder, cancer.
- Lymphocytes
- lymphocytic leukocytosis. It may also be linked
to specific lymphomas and leukemias.
- lymphocytic leukocytosis. It may also be linked
to specific lymphomas and leukemias.
- Neutrophils
- neutrophilic leukocytosis: This condition is a normal
immune response, such as infection, injury,, some
- neutrophilic leukocytosis: This condition is a normal
immune response, such as infection, injury,, some
- Eosinophils
- If a person registers high levels of eosinophils, the body might be reacting to a parasitic infection,
allergen, or asthma
- If a person registers high levels of eosinophils, the body might be reacting to a parasitic infection,
allergen, or asthma
- Basophils
- Causes
- Allergy
- Drugs
- Polycythemia vera
- Leukemia
- Stress
- Allergy
- Only one type of WBC is
affected
- Leukemoid
Reaction
- Normal response &
subsides after
eliminating the stressor
- WBC count 15,000-100,00
cells/mm3.
- Dohle bodies
- High NAP/LAP scores
- Toxic granulations
- WBC count 15,000-100,00
cells/mm3.
- Normal response &
subsides after
eliminating the stressor
- Genetic tests
- PCR
- using a blood
sample or bone
marrow cells To
find the
BCR-ABL fusion
gene
- using a blood
sample or bone
marrow cells To
find the
BCR-ABL fusion
gene
- (FISH)
- FISH can be used to
look for specific pieces
of the BCRABL gene on
chromosomes.
- FISH can be used to
look for specific pieces
of the BCRABL gene on
chromosomes.
- PCR
- Types of leukemia
- ACUTE leukemia
- > 20% blasts in bone marrow
- MYELOID
- AML
- gum infiltrates
- Auer rods
- 15-60yrs
- gum infiltrates
- AML
- LYMPHOID
- ALL
- newborns-14yrs
- B-ALL is more common
- Dense
chromatin is
found in
mature cells
- newborns-14yrs
- ALL
- MYELOID
- > 20% blasts in bone marrow
- CHRONIC leukemia
- < 20% blasts in bone marrow
- MYELOID
- CML
- 25-60 yrs
- Philadelphia
chromosome
- Splenomegaly
- Causes
- Cirrhosis
- Cystic fibrosis
- Cytomegalovirus
- Lymphoma
- Cirrhosis
- Symptoms
- Anemiaؤ
- Fatigue
- Frequent infections
- Anemiaؤ
- Causes
- Basophilia
- 25-60 yrs
- CML
- LYMPHOID
- CLL
- common in adults
- Asymptomatic
- smudge cells
- common in adults
- CLL
- MYELOID
- < 20% blasts in bone marrow
- ACUTE leukemia
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