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208233
Hepatitis Treatment
Description
ID Mind Map on Hepatitis Treatment, created by Emma Jones on 14/09/2013.
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Mind Map by
Emma Jones
, updated more than 1 year ago
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Created by
Emma Jones
about 11 years ago
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Resource summary
Hepatitis Treatment
Hepatitis B
Pegylated alpha interferon
Expensive, contraindications, side effects
No resistance
48 wks subcutaneous
eAg+ : low response, high sustained response
eAg- : high response (60%), low sustained response
Flu-like, cytopaenia, depression
Oral anti-virals: suppress viral replication
Examples
Lamivudine: no longer used due to low durability of response
Adefovir: poor response durability @5yrs
Entecavir
Tenofovir
Effectiveness: high response to treatment, low retained response
Side effects: few
1/day indefinitely
Hepatitis C
Pegylated alpha interferon + Ribavirin
Duration
Genotypes 1&4: 48 weeks, 45% success
Genotypes 2&3: 24 weeks, 80% success
Side effects
Pegylated interferon: fatigue, malaise, neutropaenia, thrombocytopaenia, depression, insomnia, weight loss, alopecia
Ribavirin: pruritis, anaemia, rash, nasal congestion
Contraindications
Interferon: severe depression, psychosis, cardiac failure, autoimmune disease, pregnancy
Ribavirin: renal failure, pregnancy
HCV N23/4A inhibitors
Boceprevir
Anaemia, dysuguesia
68% sustained response
Telaprevir
Severe rash, anaemia, nausea
75% sustained response
Clinical use
Genotype 1 only
Triple Therapy with IFN/Ribavirin: reduced tolerance due to combined side effects
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