Hepatitis Treatment

Description

ID Mind Map on Hepatitis Treatment, created by Emma Jones on 14/09/2013.
Emma Jones
Mind Map by Emma Jones, updated more than 1 year ago
Emma Jones
Created by Emma Jones about 11 years ago
57
1

Resource summary

Hepatitis Treatment
  1. Hepatitis B
    1. Pegylated alpha interferon
      1. Expensive, contraindications, side effects
        1. No resistance
          1. 48 wks subcutaneous
            1. eAg+ : low response, high sustained response
              1. eAg- : high response (60%), low sustained response
                1. Flu-like, cytopaenia, depression
                2. Oral anti-virals: suppress viral replication
                  1. Examples
                    1. Lamivudine: no longer used due to low durability of response
                      1. Adefovir: poor response durability @5yrs
                        1. Entecavir
                          1. Tenofovir
                          2. Effectiveness: high response to treatment, low retained response
                            1. Side effects: few
                              1. 1/day indefinitely
                            2. Hepatitis C
                              1. Pegylated alpha interferon + Ribavirin
                                1. Duration
                                  1. Genotypes 1&4: 48 weeks, 45% success
                                    1. Genotypes 2&3: 24 weeks, 80% success
                                    2. Side effects
                                      1. Pegylated interferon: fatigue, malaise, neutropaenia, thrombocytopaenia, depression, insomnia, weight loss, alopecia
                                        1. Ribavirin: pruritis, anaemia, rash, nasal congestion
                                        2. Contraindications
                                          1. Interferon: severe depression, psychosis, cardiac failure, autoimmune disease, pregnancy
                                            1. Ribavirin: renal failure, pregnancy
                                          2. HCV N23/4A inhibitors
                                            1. Boceprevir
                                              1. Anaemia, dysuguesia
                                                1. 68% sustained response
                                                2. Telaprevir
                                                  1. Severe rash, anaemia, nausea
                                                    1. 75% sustained response
                                                    2. Clinical use
                                                      1. Genotype 1 only
                                                        1. Triple Therapy with IFN/Ribavirin: reduced tolerance due to combined side effects
                                                    Show full summary Hide full summary

                                                    Similar

                                                    Freud's Theory of Personality
                                                    09andreonei
                                                    Intro to Horticulture Plant ID NC FFA 2015
                                                    Bethany Davis
                                                    intro to horticulture 2015 nc ffa pest ID
                                                    Bethany Davis
                                                    RNA Viruses
                                                    ravi shah
                                                    Psychodynamic Approach Practice Quiz
                                                    Carly Eddy
                                                    Non-Arboviruses
                                                    Nicolette Adamson
                                                    Micro Exam 1
                                                    stephdancer8
                                                    HIV-1 Including Current and Future Treatment Strategies
                                                    Matthew Coulson
                                                    Pendahuluan dan Sejarah Virologi
                                                    raifedora
                                                    Nursery and landscaping plant ID NC FFA 2016
                                                    Bethany Davis