233888
Pharmacology
- Naming Drugs:
chemical names,
generic names and
trade names
Annotations:
- Always use generic names in exams e.g. aspirin, paracetamol, diazepam, salbutamol Good online text: BNF
- Pharmocodynamics: the
interaction between the drug
and cell, changing normal cell
function, look at desired effect
and mode of action
Annotations:
- what does a drug do to a cell? drugs may change the environment, inhibit enzymes, react with receptors or bring about normal cell functioning
- desired effect is the purpose of taking a drug, the biochemical physical effect of the drugs, a detailed description of what a drug is used for. mode of action is how a drug does this, its mechanism
- Agonists:drugs
which bind to
receptors (like an
neurotransmitter)
which then produce
an effect within the
cell,has a
stimulating effect
and an affinity to the
receptor
- Antagonist: drugs
which bind with
receptors which
prevent a response
within the cell, it has
an affinity with the
receptor but causes
no stimulation
- competitive
antagonist:
competes with
antagonistnon
competitive
antagonist blocks all
agonists.
- competitive
antagonist:
competes with
antagonistnon
competitive
antagonist blocks all
agonists.
- Non selective drugs:
bind to any receptor
(widespread side
effects, is an older drug)
- Drug potency:
how much of a
drug needed to
give a desired
effect
- Therapeutic
index/window: the
safe does to give
a desired affect
Annotations:
- look at warfarin as an example, very small window of safe dose, most be monitored regularly, may be dangerous
- Synaptic functions: synthesis,
storage, release, binding and
activation and inactivation
Annotations:
- drugs interfer with these stages
- Drugs may: decrease synthesis
of neurotransmitters, stimulate
receptors (agonist), prevent
neurotransmitter binding to
receptors (antagonist) or drugs
may decrease the breakdown of
neurotransmitters
Annotations:
- know will these stimulate or reduce normal cell functioning
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