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Anemia caused by ↑ RBC destruction or loss

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Mind Map on Anemia caused by ↑ RBC destruction or loss, created by Sarah Phillips on 11/04/2015.
Sarah Phillips
Mind Map by Sarah Phillips, updated more than 1 year ago
Sarah Phillips
Created by Sarah Phillips over 9 years ago
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Resource summary

Anemia caused by ↑ RBC destruction or loss
  1. Intrinsic Abn
    1. Membrane Defect
      1. hereditary spheocytosis
        1. hereditary elliptocytosis
          1. pyropoikilocytosis (subset of HE)
          2. paroxysmal nocturnal hemoglobinuria
            1. hereditary stomatocytosis
              1. hereditary xerocytosis
              2. Enzyme Deficiency
                1. G6PD
                  1. pyruvate kinase
                  2. Qualitative Globin Abn
                    1. Single Amino Acid Substitutions Usually in Beta Chain
                      1. Sickle cell anemia/trait
                        1. Hgb S: anemia; Hgb SA: trait
                        2. Hgb C Dx
                          1. Hgb AC
                            1. Hgb SC
                            2. Variant Hgbs
                              1. Hgb S-beta thal
                                1. Hgb E
                                  1. Hgb D
                                    1. Hgb Lepore (delta - beta fusion)
                              2. Extrinsic Abn
                                1. Immune Causes (Ab mediated)
                                  1. Warm autoimmune hem anemia
                                    1. Cold agglutinin Dx
                                      1. Paroxysmal Cold Hemoglobinuria
                                        1. HTR & HDFN
                                          1. Immune Thrombocytopenia
                                          2. Non Immune (not Ab mediated) RBC Injury
                                            1. Microangiopathic hemolytic anemia
                                              1. Thrombotic thrombocytic anemia
                                                1. HELLP syndrome
                                                  1. DIC
                                                    1. HUS
                                                    2. Macroangiopathic hemolytic anemia
                                                      1. traumatic cardiac hemolysis
                                                      2. Infectious agents
                                                        1. malaria
                                                          1. babesiosis
                                                            1. bartonellosis
                                                              1. clostridial sepsis
                                                              2. Other injury
                                                                1. chemicals
                                                                  1. drugs
                                                                    1. burns
                                                                      1. venoms
                                                                      2. Non Megaloblastic Macrocytic Anemia
                                                                        1. RBC destruction from underlying condition: BM compensates
                                                                          1. hypothyroidism
                                                                            1. chronic liver dx
                                                                              1. alcoholism
                                                                                1. chemo
                                                                                  1. post splenectomy
                                                                              2. Acute Blood Loss
                                                                              3. ↑ Retic
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