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Pathophysiology: Immune-Mediated Atherosclerosis

Description

Brain storm showing the pathophysiology of immune-mediated AT.

Mind Map by Chadley Kemp, updated more than 1 year ago

	Created by Chadley Kemp over 9 years ago

Resource summary

Pathophysiology: Immune-Mediated Atherosclerosis

IL-1R
1. IL-1R/IL-18
  1. NFkB TF
    1. Mp/DC (Innate)
      1. Alarmins
        LPS
        oxLDL
        LDL
        CRP
        oxLDL-CRP
        Foam cells
  2. Caspase-1
    1. Inflammasome
2. Local Inflammatory cascade
3. IL-6
4. Fibrinogen
  1. Fibrin
    1. Pro-coagulant
      1. Thrombin
FcRI/CD38
1. β2-GPI-spp Ab
  1. Atheroma
    1. Myocardial Infarction
  2. oxLDL-β2GPI complex
MyD88
1. Th/Tc

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