Pathophysiology: Low estrogen production
Leading to, fatigue, hot flashes, night sweats, memory lapses, difficulty concentrating, joint pain, loss of libido.
Mechanism:
Compete with Estradiol E2 and bind to ER-rich cells.
Alter receptors of receptros for progesterone, oxytocin and testosterone.
Breast Cancer
Annotations:
Depends on age.
Cancer will proliferate in presence of oestrogen.
Treatment is usage of selective oestrogen receptors modulator.
Less likely to develop breast cancer after ingesting phytoestrogens
Omega-3 Supplements
Annotations:
Effective for depression, CV diseases,
# tyoes:
ALA (alpha linolenic acid)
EPA:(eicosapentaenoic acid)
DHA (Docosahexaenoic acid): Predominantly in brain.
Omega 3 vs Omega 6
Annotations:
omega 3 is more anti-inflammatory while omega 6 are pro inflammatory.
Diets have high n6: n3 enhances both depression and inflammatory disease'
However needs time to work, 6 - 12 weeks
Nutritional Deficiency Disease
Annotations:
B3: Needed it for DNA repair, oxidative phosphorilation
Diseases
Annotations:
Malabsorption syndromes: I.e bacterial overgrowth.
Increased loss or turnover:
Age