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TUMOR SUPPRESSORS

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Cancer Biology Mind Map on TUMOR SUPPRESSORS, created by salu624 on 26/10/2013.
salu624
Mind Map by salu624, updated more than 1 year ago
salu624
Created by salu624 about 11 years ago
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Resource summary

TUMOR SUPPRESSORS
  1. SIGNALING
    1. TGF-B PATHWAY
      1. p-15
        1. INHIBIT CYCLIN D-CDK4,6
        2. PAI-1
          1. INHIBIT MMP'S
      2. CELL CYCLE INHIBITORS
        1. LOSS OF Rb PROTEIN
          1. E2F- ON
        2. CDK INHIBITORS
          1. p21 CIP FAMILY
            1. universal inhibitors
              1. p53 INDUCED
              2. INK4 FAMILY
                1. p15
                  1. p16
                    1. MELANOMA
                    2. SPECIFIC: CYCLIN D-CDK4,6
                    3. LOSS OF p53
                      1. CAN'T ARREST CELL CYCLE PROGRESSION
                        1. CAN'T INDUCE DNA REPAIR ENZYMES
                          1. CAN'T INDUCE APOPTOSIS
                          2. BRCA-1
                            1. ENHANCE p53
                              1. ENHANCE p21
                              2. Wee1 Kinase + CDC25 phosphatase
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