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3289361
HER2 +
Description
Some characteristics about of HER2
No tags specified
polysomia
Mind Map by
puma_1921paul
, updated more than 1 year ago
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Created by
puma_1921paul
almost 9 years ago
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Resource summary
HER2 +
Human epidermal growth factor receptor
Locus Citogenético 17q12–21.32
Other genes BRCA1, TOP2A, TP53
Expresado en 20 % de los cánceres (Amplificación ERBB2)
poor prognostic more aggressive decreased survival
Treatment
Trastuzumab (monoclonal antibody)
diagnostic techniques
immunohistochemistry (IHC)
in situ hybridization (ISH)
≥3 CEP17 (Cuttoff)
Gene amplification
Increase in the copy number of a specific chromosomal region
Polisomia
Presence of extra copies of one or more whole chromosomes
disomía uniparental
dos copias de un cromosoma provienen del mismo progenitor
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