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33986826
Alzheimer's disease
Description
Mind Map on Alzheimer's disease, created by H S on 18/10/2021.
Mind Map by
H S
, updated more than 1 year ago
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Created by
H S
almost 3 years ago
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Resource summary
Alzheimer's disease
Causes
Genetic
APP
Chr 21
Neuronal repair
PSN-1/2
Chr 1/14
y-secretase
APOE
Lipid metabolism
Chr 12/19
Tau
Chr 17
Microtubule associated
Signs and symptoms
Memory loss
Limbic system
Cortical structures
Limbic lobe
Subcallosal area
Cingulate gyrus
Isthmus of limbic lobe
Parahippocampal gyrus
Uncus
Hippocampal formation
Hippocampus proper
Subiculum
Dentate gyrus
Entorhinal cortex
Septa area
Orbito-frontal cortex
Subcortical structures
Anterior nucleus of thalamus
Hypothalamus
Mammillary bodies
Amygdala
Connecting pathways
Fornix
Mammilothalamic tract
Stria temrinalis
Cingulum
Longitudinal stria
Medial forebrain bundle (MFB)
Anterior commisure
Types of memory
Short term memory
Intermediate memory
Long term memory
Sensory memory
Physiology of memory
Habituation
Inhibition of pathways
Inhibiton of presynaptic Ca2+ influx
Less release of neurotransmitters
Sensitization
Facilitation of pathways
Stimulation of presynaptic Ca2+ influx
Increased release of neurotransmitters
Dementia
Vascular dementia
Lewy body dementia
Frontotemporal dementia
Mixed dementia
Al cohol related dementia
Pathophysiology
Formation of plaques
Formation of neurofibrillary tangles
Plaques and tangles
Inflammation (neuronal injury)
Neuronal death
Disrupt neuronal signalling
Investigations
Mini-mental state examination (MMSE)
Assess
Orientation
Registeration
Attention and calculation
Recall
Language
Copying
Blood tests
CBC
ESR
Liver/kidney function tests
Blood glucose
Thyroid function tests
Blood culture
HIV test
Imaging
PET
CT/MRI
Genetic testing
Management
Drugs
Selective cholinesterase inhibitors
Rivastigmine, Galantamine, Donepezil
Side effects
DUMBELSS
Diarrhea
Urination
Myosis
Bronchospasm
Emesis
Lacrimation
Salivation/sweating
NMDA antagonist
Memantine
Side effects
Dizziness
Confusion
Hallucinations
Risk factors
Non-Modifiable
Age
Family history
Down syndrome
Head injuries
Modifiable
Cardiovascular disease
Smoking/Alcohol
Obesity
Diabetes
Hypertension
Lack of sleep
Sedentary lifestyle
Lack of education
Seizure
Strokes
Media attachments
Anatomy Of The Limbic System (binary/octet-stream)
Signs (binary/octet-stream)
The Mini Mental State Examination Q640 (binary/octet-stream)
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