33986826
Alzheimer's disease
- Causes
- Genetic
- APP
- Chr 21
- Neuronal repair
- Chr 21
- PSN-1/2
- Chr 1/14
- y-secretase
- Chr 1/14
- APOE
- Lipid metabolism
- Chr 12/19
- Lipid metabolism
- Tau
- Chr 17
- Microtubule associated
- Chr 17
- APP
- Genetic
- Signs and symptoms
- Memory loss
- Limbic system
- Cortical structures
- Limbic lobe
- Subcallosal area
- Cingulate gyrus
- Isthmus of limbic lobe
- Parahippocampal gyrus
- Uncus
- Subcallosal area
- Hippocampal formation
- Hippocampus proper
- Subiculum
- Dentate gyrus
- Entorhinal cortex
- Hippocampus proper
- Septa area
- Orbito-frontal cortex
- Limbic lobe
- Subcortical structures
- Anterior nucleus of thalamus
- Hypothalamus
- Mammillary bodies
- Mammillary bodies
- Amygdala
- Anterior nucleus of thalamus
- Connecting pathways
- Fornix
- Mammilothalamic tract
- Stria temrinalis
- Cingulum
- Longitudinal stria
- Medial forebrain bundle (MFB)
- Anterior commisure
- Fornix
- Cortical structures
- Types of
memory
- Short term memory
- Intermediate memory
- Long term memory
- Sensory memory
- Short term memory
- Physiology of memory
- Habituation
- Inhibition of pathways
- Inhibiton of presynaptic Ca2+ influx
- Less release of neurotransmitters
- Inhibition of pathways
- Sensitization
- Facilitation of pathways
- Stimulation of presynaptic Ca2+ influx
- Increased release of neurotransmitters
- Facilitation of pathways
- Habituation
- Limbic system
- Memory loss
- Dementia
- Vascular dementia
- Lewy body dementia
- Frontotemporal dementia
- Mixed dementia
- Al cohol related dementia
- Vascular dementia
- Pathophysiology
- Formation of plaques
- Formation of neurofibrillary tangles
- Plaques and tangles
- Inflammation (neuronal injury)
- Neuronal death
- Disrupt neuronal signalling
- Inflammation (neuronal injury)
- Formation of plaques
- Investigations
- Mini-mental state examination (MMSE)
- Assess
- Orientation
- Registeration
- Attention and calculation
- Recall
- Language
- Copying
- Orientation
- Assess
- Blood tests
- CBC
- ESR
- Liver/kidney function tests
- Blood glucose
- Thyroid function tests
- Blood culture
- HIV test
- CBC
- Imaging
- PET
- CT/MRI
- PET
- Genetic testing
- Mini-mental state examination (MMSE)
- Management
- Drugs
- Selective cholinesterase inhibitors
- Rivastigmine, Galantamine, Donepezil
- Side effects
- DUMBELSS
- Diarrhea
- Urination
- Myosis
- Bronchospasm
- Emesis
- Lacrimation
- Salivation/sweating
- Diarrhea
- DUMBELSS
- Rivastigmine, Galantamine, Donepezil
- NMDA antagonist
- Memantine
- Side effects
- Dizziness
- Confusion
- Hallucinations
- Dizziness
- Memantine
- Selective cholinesterase inhibitors
- Drugs
- Risk factors
- Non-Modifiable
- Age
- Family history
- Down syndrome
- Head injuries
- Age
- Modifiable
- Cardiovascular disease
- Smoking/Alcohol
- Obesity
- Diabetes
- Hypertension
- Lack of sleep
- Sedentary lifestyle
- Lack of education
- Seizure
- Strokes
- Cardiovascular disease
- Non-Modifiable
Media attachments
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