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35661015
Dopaminergic Pathways
Description
Mind Map on Dopaminergic Pathways, created by J.J. Lopez on 27/02/2022.
Mind Map by
J.J. Lopez
, updated more than 1 year ago
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J.J. Lopez
over 2 years ago
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Resource summary
Dopaminergic Pathways
Mesolimbic Pathway
In charge of Motivation, emotions, reward and positive symptoms
Moves DA from VTA to NA
Ventral Tegmental Area
Nucleus Accumbens
mediating motivational and emotional processes
Image
Lots of dopamine in Schizophrenia patients
Mesocortical Pathway
In charge of motivation, emotion, and executive functions.
Little dopamine in Schizophrenia patients
This causes negative symptoms
First gen antipsicotics lower DA even more
This leads to a constant state of negative symptoms
Second Gen helps with this
Runs from VTA to Cortex
Image
Nigrostriatal Pathway
DA from SN to Striatum
SN: Substantia Nigra
Striatum: Caudate + Putamen
Mediate motor movment
Image
Blockade of Dopamine leads to:
Parkinsons or EPS
EPS: Extraprimidal Symptoms
Akathisia
Fidgeting
Feeling restless like you can’t sit still. You may have the urge to tap your fingers, fidget, or jiggle your legs.
Dystonia
Involuntary Muscles
When your muscles contract involuntarily. It can be painful.
Parkinsonism
Tremors
Symptoms are similar to Parkinson’s disease. You may have a tremor, difficulty finishing thoughts or speaking, and stiff facial muscles
Tardive dyskinesia
Involuntary Face
Facial movements happen involuntarily. You may make a sucking or chewing motion with your mouth, stick out your tongue, or blink your eyes a lot.
Tuberoinfundibular Pathway
Moves from the HT to to PG
HT: Hipothalamus
PG: Pituitary Gland
Image
Blocking D2 Receptors leads to:
Hyperprolactinemia, which manifests as:
Amenorrea
Lack of Period
Galactorrea
A milky nipple discharge unrelated to the normal milk production of breast-feeding.
Can occur in women and men
Sexual Dysfunction
The TI pathway inhibits prolactin release
Prolactin causes the breasts to grow and make milk during pregnancy and after birth.
Media attachments
Mesolimbic Pathway2 (binary/octet-stream)
Mesocortical Pathway (binary/octet-stream)
Nigrostriatal Pathway (binary/octet-stream)
7 Tuberoinfundibular Pathway Prolactine Release (binary/octet-stream)
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