35661015
Description
Mind Map by J.J. Lopez, updated more than 1 year ago
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Created by J.J. Lopez
over 2 years ago
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Dopaminergic Pathways
- Mesolimbic Pathway
- In charge of Motivation, emotions, reward and positive symptoms
- Moves DA from VTA to NA
- Ventral Tegmental Area
- Nucleus Accumbens
- mediating motivational and emotional processes
- mediating motivational and emotional processes
- Image
- Ventral Tegmental Area
- Lots of dopamine in Schizophrenia patients
- In charge of Motivation, emotions, reward and positive symptoms
- Mesocortical Pathway
- In charge of motivation, emotion, and executive functions.
- Little dopamine in Schizophrenia patients
- This causes negative symptoms
- First gen antipsicotics lower DA even more
- This leads to a constant state of negative symptoms
- Second Gen helps with this
- This leads to a constant state of negative symptoms
- Runs from VTA to
Cortex
- Image
- Image
- This causes negative symptoms
- In charge of motivation, emotion, and executive functions.
- Nigrostriatal Pathway
- DA from SN to Striatum
- SN: Substantia Nigra
- Striatum: Caudate + Putamen
- SN: Substantia Nigra
- Mediate motor movment
- Image
- Blockade of Dopamine leads to:
- Parkinsons or EPS
- EPS: Extraprimidal Symptoms
- Akathisia
- Fidgeting
- Feeling restless like you can’t sit still. You may have the urge to tap your fingers, fidget, or jiggle your
legs.
- Feeling restless like you can’t sit still. You may have the urge to tap your fingers, fidget, or jiggle your
legs.
- Fidgeting
- Dystonia
- Involuntary Muscles
- When your muscles contract involuntarily. It can be painful.
- When your muscles contract involuntarily. It can be painful.
- Involuntary Muscles
- Parkinsonism
- Tremors
- Symptoms are similar to Parkinson’s disease. You may have a tremor, difficulty finishing thoughts or
speaking, and stiff facial muscles
- Symptoms are similar to Parkinson’s disease. You may have a tremor, difficulty finishing thoughts or
speaking, and stiff facial muscles
- Tremors
- Tardive dyskinesia
- Involuntary Face
- Facial movements happen involuntarily. You may make a sucking or chewing motion with your mouth,
stick out your tongue, or blink your eyes a lot.
- Facial movements happen involuntarily. You may make a sucking or chewing motion with your mouth,
stick out your tongue, or blink your eyes a lot.
- Involuntary Face
- Akathisia
- EPS: Extraprimidal Symptoms
- Parkinsons or EPS
- DA from SN to Striatum
- Tuberoinfundibular Pathway
- Moves from the HT to to PG
- HT: Hipothalamus
- PG: Pituitary Gland
- Image
- HT: Hipothalamus
- Blocking D2 Receptors leads to:
- Hyperprolactinemia, which manifests as:
- Amenorrea
- Lack of Period
- Lack of Period
- Galactorrea
- A milky nipple discharge unrelated to the normal milk production of breast-feeding.
- Can occur in women and men
- Can occur in women and men
- A milky nipple discharge unrelated to the normal milk production of breast-feeding.
- Sexual Dysfunction
- Amenorrea
- Hyperprolactinemia, which manifests as:
- The TI pathway inhibits prolactin release
- Prolactin causes the breasts to grow and make milk during pregnancy and after birth.
- Prolactin causes the breasts to grow and make milk during pregnancy and after birth.
- Moves from the HT to to PG
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