Exam 2: Thiazolidinediones

Pharmacological action
1. Decrease insulin resistance
  1. In turn increases sketeletal muscle and adipose tissue uptake
2. Decrease liver glucose production
Pharmacokinetics
1. Metabolized in liver
2. Excreted via feces (mostly) and urine
Adverse effects
1. Unintended ovulation
2. Bladder cancer
3. Fluid retention
4. Increased cholestrol
5. Risk for bone fracture
6. URIs/ sinusitis
7. Headaches
8. Muscle aches
Contraindications
1. Liver impairment
2. Bladder cancer
3. Heart failure
Drug interactions
1. Insulin
  1. Fluid retention
  2. Hypoglycemia
2. Hypoglycemia
  1. Gemfibrozil
  2. Coenzyme Q10
  3. Ketoconazole
  4. Chromium
Extra information
1. Also known as glitazones
2. Pioglitazone is a medication in this category
Nursing interventions
1. Liver Function Tests at baseline & every 3-6 months

Resource summary

	Created by Jasper McClellan about 2 years ago