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Hereditary WBC Disorders

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BASIC WBC Disorders Martha Mind Map on Hereditary WBC Disorders, created by Martha Richardson on 22/11/2013.
Martha Richardson
Mind Map by Martha Richardson, updated more than 1 year ago More Less
KevinShirley
Created by KevinShirley about 11 years ago
Martha Richardson
Copied by Martha Richardson about 11 years ago
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Resource summary

Hereditary WBC Disorders
  1. May-Hegglin Anomaly
    1. Associated Conditions

      Annotations:

      • Abnormal bleeding may be present in some individuals.
      1. thrombocytopenia
        1. giant platelets
        2. WBC's affected
          1. neutrophils
          2. appearance
            1. Döhle-like bodies

              Annotations:

              • Rod shaped inclusions at the edge of the cytoplasm. They are like Döhle bodies but larger.
            2. prevalence
              1. unknown
            3. Alder-Reilly Anomaly
              1. Associated Conditions
                1. dwarfism
                  1. gargoylism
                  2. WBC's affected
                    1. All cell lines
                      1. hallmark feature
                    2. Appearance
                      1. coarse dark granulation
                      2. prevalence
                        1. rare
                      3. Pelger-Huet Anomaly
                        1. prevalence
                          1. common
                          2. associated conditions
                            1. leukemias
                              1. myleoproliferative disorders
                                1. severe infections
                                2. WBC's affected
                                  1. segmented neutrophils
                                  2. appearance
                                    1. hyposegmentation of nucleus
                                      1. heterozygotes
                                        1. peanut-shaped
                                          1. dumbbell-shaped
                                            1. pince-nez-shaped
                                            2. homozygotes
                                              1. spherical non-lobed
                                        2. Chediak-Higashi Syndrome
                                          1. prevalence
                                            1. rare
                                            2. associated conditions
                                              1. neutropenia
                                                1. albinism
                                                  1. photophobia
                                                    1. recurrent staphylococcus infections
                                                    2. WBC's affected
                                                      1. neutrophils (mostly)
                                                        1. lymphocytes
                                                          1. monocytes
                                                          2. appearance
                                                            1. giant purple-gray granules
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