BetaLactams

BetaLactams

Mechanism
1. Prevent crosslinking of peptidoglycans
2. Bactericidal
3. Renal adjusted
Penicilins
1. Antistaphylococcal
  1. AE: Neutropenia
    1. Tissue necrosis
      1. Interstitial Nephritis
  2. Naficillin, Oxacillin, Dicloxacillin
  3. MSSA, Endocarditis, Meningitis, Osteomylitis
2. Aminopenicillin
  1. AE: Thrombocytopenia
    1. Diarrheaa
  2. Enterococcal (doc), UTI, SSSI
  3. Amoxicillin, Ampicillin
3. Extended Spectrum
  1. AE: Diarrhea
    1. Thrombocytopenia
  2. Piperacillin, Ticarcillin
  3. HAI, UTI, SSSI
4. AE: Hepatitis
  1. Seizure
    1. Hemolytic anemia
5. Tons of resistance pencillinase
6. Syphillis (doc), Grp A Strep
Cephalosporin
1. Ist Gen
  1. Surgical Prophylaxis, MSSA (doc)
    1. Cephalexin, Cefazolin
2. 2nd Gen
  1. URI
    1. Cefuroxieme, Cefoxitin
3. 3rd Gen
  1. Strep pneumo, meningitis, URI
    1. Ceftriaxone = meiningitis
4. 4th Gen
  1. MDRO, Cellulitis, PNA, CNS, UTI
    1. Cefepime
    2. Gram -ves: Pseudomonas, E. Coli, Klebsiella
5. 5th Gen
  1. MRSA!
    1. Ceftaroline
Carbapenems
1. Gram (+): Stap, Strep, Entero, Listeria
  1. Gram (-): Pseudomonas, SPACE
    1. Anaerobes: B. Fragilis
      1. PNA, MDRO, SSSI,
2. AE: Seizures
  1. Thrombocytopenia
    1. Transaminitis
3. Imipenem (seizure); Ertapenem (NO pseudomonas)
  1. Meropenem (CNS); Doripenem

Resource summary

	Created by Josh Woody about 9 years ago