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420109
Antiinfective Drugs
Description
(DHYG 325- Pharmacology) Mind Map on Antiinfective Drugs , created by fandrickb2 on 05/12/2013.
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dhyg 325- pharmacology
dhyg 325- pharmacology
Mind Map by
fandrickb2
, updated more than 1 year ago
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Created by
fandrickb2
over 10 years ago
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Resource summary
Antiinfective Drugs
Bacteriocidal
Drugs that interfere with the cell wall
Penecillins, cephalosporins, bacitracin
Penicillins
Gram + cocci
Penicillinase resistant: enzyme produced by staphylococci making it microbe resistant.
Extended spectrum g+/-: e coli, H influenzae, proteus mirabilis
ampicillin, amoxocillin: claculanic acid is penicillinase resistant.
Cephalosporins: spectrum varies w each generation + to more -
10% cross hypersensitivity w penicillin
Drugs that interfere with the cell membrane
antifungals: nystatin, ketoconazole, clotrimazole
Bacteriostatic
drugs that interfere with protein synthesis:
metronidazole, tetracyclines, clindamycin, erythromycin
Tetracyclines: broad spectrum (gram +/-)
bind to calcium: bad for pregnat/breastfeeding women
ADR: GI upset, stomatitis, superinfection, photosensitivity, enamel hypoplasia,tooth staining
Macrolides: gram + microbes
used in ppl w penicillin allergies (clarithromycin & azithromycin common in dentistry)
ADR: GI upset , stomatitis, candidiasis
Interactions: eryth: bronchodialator (inc theophylline levels), inc. warfarin effect, dec. Birth control pill effect
Metronidazole: inhibits PRO synthesis (not normal)
perio anaerobic infections: NUG/NUP
avoid alcohol (food, drink, rinses)
Antifolates
drugs that interfere with nucleic acid synthesis
sulfa, quinalones (ciprofloxacin & norfloxacin), & antiTB drugs (rifampin & isoniazid)
Fluoroquinolones: affect bacterial DNA
avoid elecive dental Tx if TB+
Dr consult to confirm liver function
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