Deep Venous Thrombosis

Pathophysiology
1. Activation of blood coagulation
2. Vein damage
3. Venous Stasis
Treatment
1. Anticoagulant therapy
  1. Heparin, warfarin, Factor Xa inhibitors
    1. Fondaparinux, Rivaroxaban
    2. LMWH (enoxaparin),UFH
2. Endovascular and Surgical Interventions
  1. Pharmacologic thrombolysis
  2. Thrombolysis
  3. Mechanical Thrombectomy
  4. Angioplasty and stenting
  5. IVC filter
Diagnosis
1. D-Dimer Testing
2. Coagulation profile
3. Ultrasonography
4. Diagnostic Imaging
  1. CT scan
    1. Ventilation-Perfusion (V/Q) scan
  2. Pulmonary angiography
5. Genetic Laboratory Testing
6. Venography
7. Wells Clincal Predictor
Epidemiology
1. Common cause of morbidity and mortality
  1. 1 out of 20 people develop DVT over lifetime
    1. Existing data suggest 80 cases per 100,000 annually
      1. Usually affects those over 40 years old
      2. Male-to-female ratio is 1:2:1( higher risk in males)
        Increase with age in both sexes
2. Exact incidence is not unknown due to limited studies
Clinical Manifestations
1. Positive Homans sign
  1. Pain, warmth, and edema of limb
    1. Variable discoloration of limb
2. "Silent" pulmonary embolism
3. Visible veins
4. Symptoms of PE
  1. SOB, chest pain, rapid breathing, hemoptysis

Resource summary

	Created by angelle.williams almost 9 years ago