4758305
Description
Mind Map by Lindie Metz, updated more than 1 year ago
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Created by Lindie Metz
almost 9 years ago
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Cholinergic Drugs
- Receptor: Muscarininc
- Heart, smooth muscles, brain,
exocrine glands
- Heart, smooth muscles, brain,
exocrine glands
- Receptor: Nicotinic
- CNS, adrenal medulla,
autonomic ganglia, NMJ
- CNS, adrenal medulla,
autonomic ganglia, NMJ
- CH Agonist
- Direct acting
- Parasympathomimetics.
Mimics Ach by binding
directly to Ch receptors.
Longer duration.
- Bethanecol
- Muscarinic action,
bradycardia, increased
excretion,
bronchoconstriction, inc
in GIT, dilate BV
- Urinary retention, esp
postpartum/postopertive
- Hypotension, bronchoconstriction,
excessive excretion, dysrhythmia in
hyperthyroid pt
- Urinary obstruction,
hyperthyroid pt
- Urinary obstruction,
hyperthyroid pt
- Hypotension, bronchoconstriction,
excessive excretion, dysrhythmia in
hyperthyroid pt
- Oral, 1 hr
- Urinary retention, esp
postpartum/postopertive
- Muscarinic action,
bradycardia, increased
excretion,
bronchoconstriction, inc
in GIT, dilate BV
- Pilocarpine
- Topical appl to
produce rapid meiosis,
cilliary contraction
- Glaucoma by lowering
of intra-ocular pressure
- Blurred vision,
nightblind, brow ache
- Blurred vision,
nightblind, brow ache
- Topical, 4-8 hrs
- Glaucoma by lowering
of intra-ocular pressure
- Topical appl to
produce rapid meiosis,
cilliary contraction
- Parasympathomimetics.
Mimics Ach by binding
directly to Ch receptors.
Longer duration.
- Indirect acting
- Anti-cholinesterases,
leading to accumilation of
ACh, broad spectrum
- Neostigmine
- ChE splits N slower than
ACh, bradychardia,
bronchoconstriction, incr
excretion, urination, GI
motility
- Myasthenia Gravis
- Excessive muscarinic
stim: salivation, inc
GI, urinary urgency,
bradychardia,
sweating, miosis
- GI/Urinary obstruction,
peptic ulcer, asthma,
hyperthyroidism
- GI/Urinary obstruction,
peptic ulcer, asthma,
hyperthyroidism
- Excessive muscarinic
stim: salivation, inc
GI, urinary urgency,
bradychardia,
sweating, miosis
- Orally
- Myasthenia Gravis
- ChE splits N slower than
ACh, bradychardia,
bronchoconstriction, incr
excretion, urination, GI
motility
- Anti-cholinesterases,
leading to accumilation of
ACh, broad spectrum
- Direct acting
- CH Antagonist
- Agents that bind to Ch
receptors to prevent
action
- Anti-muscarinic
- Parasympatholitic.
Block muscarinic
receptors. Little effect
on skeletal NMJ or
autonomic ganglia
- Atropine
- Muscarinic block, incr HR,
decrease secretions,
bronchorelaxarion,
decrease GI/Urinary,
mydriasis, mild
CNSstimulation
- Pre-anaesthetic to
prevent brachycardia
- Xerostomia, inc intra-ocular P,
urinary retention, constipation,
anhydrosis
- Antihistamine
- Hallucinations, children are sensitive
- Hallucinations, children are sensitive
- Antihistamine
- Xerostomia, inc intra-ocular P,
urinary retention, constipation,
anhydrosis
- Orally, topically, IV, IM, suncutaneous
- Pre-anaesthetic to
prevent brachycardia
- Reverse effect
- Muscarinic block, incr HR,
decrease secretions,
bronchorelaxarion,
decrease GI/Urinary,
mydriasis, mild
CNSstimulation
- Scopolamine
- Anti-motion sickness,
block short-term
memory, sedation
- Topical patch
- Anti motion sickness
and post operative
nausea and vomiting
- Dry mouth, blurred vision,
tachycardia, urinary
retention. CNS – restless,
confusion, hallucinations
- Dry mouth, blurred vision,
tachycardia, urinary
retention. CNS – restless,
confusion, hallucinations
- Topical patch
- Anti-motion sickness,
block short-term
memory, sedation
- Parasympatholitic.
Block muscarinic
receptors. Little effect
on skeletal NMJ or
autonomic ganglia
- NM-Blockers
- De-polarising
- Binds to Ach receptor, but then
remains in state of depolarisation
- Succinylcholine
- See above. Constant
depolarization causes muscle
paralysis, pesists until drug
levels decline and dissociate
from receptors
- IV, 1-10 min
- Muscle relaxation (endotracheal
intubation, endoscopy)
- Hyperkalemia, postop
muscle pain, malignant
hyperthermia, apnea
- Hyperkalemia, postop
muscle pain, malignant
hyperthermia, apnea
- IV, 1-10 min
- Don't mix
- See above. Constant
depolarization causes muscle
paralysis, pesists until drug
levels decline and dissociate
from receptors
- Binds to Ach receptor, but then
remains in state of depolarisation
- Non-depolarising
- Compete with Ach, do not
depolarise motor end-plate
- Cisantracurium
- Block activation of Ach,
muscle relaxes
- IV, 1 min - 1hr
- Skeletal muscle relaxation (surgery, mech
ventilation, endotracheal intubation,
hypotension d/t release of histamine/block
nicotinic receptors, no effect on CNS
- Respiratory arrest, hypotension
- Respiratory arrest, hypotension
- IV, 1 min - 1hr
- Block activation of Ach,
muscle relaxes
- Compete with Ach, do not
depolarise motor end-plate
- Blocks nicotinic receptors
@ NMJ, causing skeletal
muscle relaxation
- De-polarising
- Agents that bind to Ch
receptors to prevent
action
- Parasympathetic
- Slows HR
- Increase gastric secretion
- Constrict pupil
- Empty bladder/bowel
- Empty bladder/bowel
- Constrict pupil
- Increase gastric secretion
- Slows HR
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