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C3

Description

Complement pathways
Amaal Salhieh
Mind Map by Amaal Salhieh, updated more than 1 year ago
Amaal Salhieh
Created by Amaal Salhieh almost 9 years ago
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Resource summary

C3
  1. iC3
    1. D Cleaves B into Ba and Bb
      1. Ba is released
        1. Bb + iC3 = iC3b
          1. iC3b
            1. cleaves C3 into C3a and C3b
              1. C3b attaches to pathogen
                1. D cleaves B into Ba and Bb
                  1. C3b + Bb = C3bBb
                    1. alternative C3 convertase
                      1. alternative C5 convertase
                        1. C3b2Bb
                          1. Cleaves C5 into C5a and C5b
                            1. C5b initiates membrane-attack complex
                              1. C6, C7, C8 bind
                                1. C9 polymerizes
                              2. C5a
                                1. Analphylatoxins
                            2. + C3b
                          2. Ba is released
                          3. B
                          4. C3a
                            2. classical C3 convertase
                              1. C4bC2a
                                1. C2a
                                  1. C2
                                      1. C2b
                                    2. C4b
                                      1. C4
                                        1. cleaves
                                          1. MASP2
                                            1. Lectin Pathway
                                            2. C1s
                                              1. CRP
                                                1. binds to C1q
                                                  1. C1r cuts itself
                                                    1. C1r cuts other C1r
                                                      1. <-- C1r cuts both C1s
                                                        1. C1s
                                                    2. Classical Pathway
                                                2. C4a
                                                  1. Anaphylatoxins
                                      2. soluble C3 convertase
                                    3. B
                                    4. Hydrolysis
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