514384
Description
Mind Map by v.djabatey, updated more than 1 year ago
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Created by v.djabatey
almost 11 years ago
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pulmonary hypertension
- causes
- pulmonary
arterial
hypertension
- idiopathic
- sporadic
- familial
- sporadic
- post-tricuspid shunts
- VSD
- AVSD
- PDA
- VSD
- HIV infection
- persistent
pulmonary
hypertension of
newborn
- idiopathic
- pulmonary
venous
hypertension
- left-sided
heart
disease
- pulmonary
vein
stenosis or
compression
- left-sided
heart
disease
- pulmonary
hypertension w/
respiratory disease
- obstructive
sleep apnoea
or upper
airway
obstruction
- chronic
obstructive
or premature
lung disease
- interstitial lung disease
- obstructive
sleep apnoea
or upper
airway
obstruction
- pulmonary thromboembolic disease
- pulmonary
inflammatory or
capillary disease
- pulmonary
arterial
hypertension
- =high pulmonary Pa, mean > 25mmHg
- most kids w/ pul HTN have a large
post-tricuspid shunt w/ high pul blood
flow & low resistance
- e.g. VSD, AVSD, PDA
- e.g. VSD, AVSD, PDA
- Pa falls to normal if
defect surgically
corrected within 6
months old
- if left untreated
- high flow and Pa causes
irreversible damage to
pulmonary vascu bed (pul
vasc disease)
- not correctable
except by
heart/lung
transplant
- not correctable
except by
heart/lung
transplant
- high flow and Pa causes
irreversible damage to
pulmonary vascu bed (pul
vasc disease)
- most kids w/ pul HTN have a large
post-tricuspid shunt w/ high pul blood
flow & low resistance
- Rx
- act on
pulmonary
vasc on
cGMP
pathway
- inhaled nitric oxide
- iv magnesium sulphate
- oral
phosphodiesterase
inhibitors
- e.g. sildenafil
- e.g. sildenafil
- inhaled nitric oxide
- act on
cAMP
pathway
- iv
prostacyclin
- inhaled iloprost
- iv
prostacyclin
- endothelin receptor antagonists
- oral Bosentan
- oral Bosentan
- anticoagulation
- heparin
- aspirin
- warfarin
- heparin
- to delay
transportation
- act on
pulmonary
vasc on
cGMP
pathway
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