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514384
pulmonary hypertension
Description
Paediatrics (Cardio) Mind Map on pulmonary hypertension, created by v.djabatey on 29/01/2014.
No tags specified
cardio
paediatrics
paediatrics
cardio
Mind Map by
v.djabatey
, updated more than 1 year ago
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Created by
v.djabatey
over 10 years ago
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Resource summary
pulmonary hypertension
causes
pulmonary arterial hypertension
idiopathic
sporadic
familial
post-tricuspid shunts
VSD
AVSD
PDA
HIV infection
persistent pulmonary hypertension of newborn
pulmonary venous hypertension
left-sided heart disease
pulmonary vein stenosis or compression
pulmonary hypertension w/ respiratory disease
obstructive sleep apnoea or upper airway obstruction
chronic obstructive or premature lung disease
interstitial lung disease
pulmonary thromboembolic disease
pulmonary inflammatory or capillary disease
=high pulmonary Pa, mean > 25mmHg
most kids w/ pul HTN have a large post-tricuspid shunt w/ high pul blood flow & low resistance
e.g. VSD, AVSD, PDA
Pa falls to normal if defect surgically corrected within 6 months old
if left untreated
high flow and Pa causes irreversible damage to pulmonary vascu bed (pul vasc disease)
not correctable except by heart/lung transplant
Rx
act on pulmonary vasc on cGMP pathway
inhaled nitric oxide
iv magnesium sulphate
oral phosphodiesterase inhibitors
e.g. sildenafil
act on cAMP pathway
iv prostacyclin
inhaled iloprost
endothelin receptor antagonists
oral Bosentan
anticoagulation
heparin
aspirin
warfarin
to delay transportation
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