514485
Description
Mind Map by lucy.wright73, updated more than 1 year ago
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Created by lucy.wright73
almost 11 years ago
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The link reaction
- Converts pyruvate (from glycolysis) to acetate. NAD is
reduced.
- Decarboxylation and dehydrogenation are
enzyme catalysed reactions (pyruvate is
substrate)
- Pyruvate dehydrogenase removes
H atoms; pyruvate decarboxylase
removes a carboxyl group
- Coenzyme NAD accepts the H
atoms; coenzyme A (CoA)
accepts the acetate > acetyl CoA
- Pyruvate dehydrogenase removes
H atoms; pyruvate decarboxylase
removes a carboxyl group
- Decarboxylation and dehydrogenation are
enzyme catalysed reactions (pyruvate is
substrate)
- Takes place in the matrix, so
pyruvate has to be transported
into mitochondria from the
cytoplasm
- 2 pyruvate + 2 NAD+ (oxidised) + 2 CoA ------> 2 CO2 + 2 reduced NAD + 2 acetyl
CoA
- No ATP produced, but each NADH
carrying 2 H atoms - will take to inner
mitochondrial membrane where H atoms
used to produce ATP during oxidative
phosphorylation
- 2 molecules of everything because
two molecules of pyruvate derived
from each glucose molecule
- No ATP produced, but each NADH
carrying 2 H atoms - will take to inner
mitochondrial membrane where H atoms
used to produce ATP during oxidative
phosphorylation
- Pyruvate is 3C, acetate is 2C, acetyl CoA is 2C
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