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519138
Haemopoeisis
Description
Paediatrics (Haematological disorders) Mind Map on Haemopoeisis, created by v.djabatey on 31/01/2014.
No tags specified
haematological disorders
paediatrics
paediatrics
haematological disorders
Mind Map by
v.djabatey
, updated more than 1 year ago
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Created by
v.djabatey
almost 11 years ago
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Resource summary
Haemopoeisis
process that maintains lifelong productn of blood cells
main site
in fetal life
=liver
postnatal life
= bone marrow
origin of all haematopoeitic cells
= pluripotent haemopoietic stem cells
crucial for normal bone productn
deficiency-> bone marrow failure
need stem cells to continuously replace dying cells
can be used for Rx
e.g. stem cell transplantation into kids w/ bone marrow failure
in the fetus
types of Hb
btw 4 & 8 week's gestation
embryonic Hb
Hb Gower 1
2 xi chains & 2 episilon chains
Hb Gower 2
2 alpha chains & 2 episilon chains
Hb Portland
2 xi chains & 2 gamma chains
> 8 weeks' gestation
HbF (fetal Hb)
main Hb during fetal life
composition
2 alpha chains & 2 gamma chains
higher affinity than adult Hb
so holds on to O2 better
imp cos fetal env hypoxic
in newborn
types of Hb present @ birth (all 3)
HbF
=74%
HbA
=25%
HbA2
=1%
type of Hb present in 1st year of life
HbF replaced by HbA & HbA2
Hb value
at birth
high
cos compensating for low [O2] in fetus
14-21.5 g/dl
in 1st few weeks
falls
10g/dl @ 2 months old
pretermies have steeper fall
6.5 -9g/dl at 4-8 weeks chronological age
higher WCC than in older kids
10-25 x 10^9/L
platelets counts @ birth are in normal range
150-400 x 10^9/L
children 1 year and above
Hb types
HbA
=97%
HbA2
=25%
proportion of HbF
very low in healthy kids
if increased is sensitive indicator of haemoglobinopathies
normal av blood vol varies w/ gest age
healthy term infants
80ml/kg
preterm infants
100 ml/kg
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