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6057473
Th1L07 Competitive and non-competitive inhibitors
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Medicine Y1 (Theme 1 | Cells and organelles) Mind Map on Th1L07 Competitive and non-competitive inhibitors, created by Emma Allde on 17/08/2016.
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medicine y1
theme 1 | cells and organelles
Mind Map by
Emma Allde
, updated more than 1 year ago
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Emma Allde
almost 8 years ago
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Resource summary
Th1L07 Competitive and non-competitive inhibitors
Competitive inhibitors
block the enzyme active site
Alter the apparent Km not the Vmax
Increase the [S] it takes to reach Vmax
Reduces the steepness of the slope
E.g. Malonate
Inhibits succinate dehydrogenase
Takes up the active site, blocking succinate (the substrate) from entering the succinate dehydrogenase
Non-competitive
reversible or irreversible
cannot reach the same Vmax
Km and Vmax/2 is the same
Does not directly block the active site
Interfere in some other way with the catalytic mechanisms
irreversibly poisons the enzyme
e.g. chealator (EDTA)
Reversible non-competitive enzyme inhibitor
Inhibits Mg2+ requiring enzyme
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