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Platelets

Platelet stimulation
1. Adhesion
2. Activation
3. Aggregation
Drugs
1. Aspirin: inhibits COX
  1. Indications
    1. Reduce fever
    2. Pain
    3. Anti-inflammatory
    4. Anti-platelet
    5. Acute MI
    6. Acute coronary syndromes
    7. Acute thrombotic stroke
    8. MI prevention
  2. Side effects
    1. Peptic ulcers
    2. Bleeding
    3. Hyperventilation
    4. Reye syndrome
    5. Tinnitus
2. Ticlopidine, clopidogrel, ticagreolor, prasugrel: block the ADP receptor
3. Abciximab, eptifibatide, tirofiban: inhibits Gp IIb/IIIa
Disorder symptoms
1. Bleeding from the mucous membranes
2. Epistaxis
3. Petechiae
4. Purpura
Platelet disorders
1. Immune thrombocytopenia purpura (ITP)
  1. Treatment
    1. Steroids
    2. IVIG
    3. Splenectomy
2. Thrombotic thrombocytopenic purpura (TTP)
3. Bernard-Souiler syndrome
4. Glanzmann thrombasthenia
DIC
1. Sepsis
2. Trauma
3. OB complications
4. Pancreatitis
5. Malignancy
6. Transfusion

Platelets

	Created by snlogel over 10 years ago