The stages of
spermatogenesis occur in the
seminiferous tubule
The lumen of the
seminiferous tubule
contains the mature
spermatozoa
Oogenesis in Females
Unequal cytokinesis occurs in oogenesis
Typically completed in ovary
Steps leading to implantation of an embryo in the nucleus
1. Follicle Stimulating
Hormone (FSH) and
Luteinizing Hormone (LH)
cause follicles to enlarge and
mature
2. Follicle cells produce
estrogen which causes the
endometrium of the uterus to
thicken
Uterus
Endometrium:
thickens and is shed
in the menses
Myometrium:
smooth
muscle layer
3. Primary oocyte
completes meiosis I and
begins meiosis II
4. LH surge causes ovulation. Secondary
oocyte (metaphase II) moves into the
fallopian tube
5. Ruptured follicle or corpus luteum produces estrogen and progesterone. These hormones cause the uterine lining to thicken
6. Fertilization occurs in the
fallopian tubes.
If fertilization does not occur, the
corpus luteum degenerates and
uterine lining is shed
7. After fertilization occurs,
the secondary oocyte
completes meiosis II
8. Ootid
matures
into an
ovum
9. Fusion of the male
pronucleus with the
female pronucleus -
2N zygote
10. Corpus luteum continues to
produce estrogen and progesterone
to keep the endometrium thick and
ready for implantation
11. Zygote divides
mitotically as it travels
to the uterus
12. Embryo
implants into the
endometrium of
the uterus
13. The embryo produces the hormone
choriogonadotropin which maintains the
corpus luteum. Corpus luteum produces high
quantities of progesterone to maintain the
endometrium
14. Formation of the placenta
Chorio-allantoic membrane of foetus
+ endometrium of mother
Site of oxygen/carbon dioxide
exchange; nutrient/waste
exchange; hormone production
Prenatal Diagnosis
Indications for Prenatal Diagnosis
Family history of a genetic disease;
ethnic background with known risk;
paternal or maternal disease; adverse
outcome of previous pregnancy; maternal
age; exposure to teratogens, radiation,
etc.
Can provide information on:
chromosomal abnormalities, protein
levels (enzymes or structural
proteins), identification of a specific
mutation through DNA analysis, other
metabolite levels
Ultrasound
Accurate date of pregnancy, multiple gestations, size &
position of placenta, amount of amniotic fluid, some
internal abnormalities and skeletal defects can be seen,
foetal sex, foetal growth and development
Chorionic Villi Sampling (CVS)
Tiny pieces of
chorionic villi
removed and villi
cells are cultured