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I always feel tired

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Mind Map on I always feel tired, created by leen abuafifeh on 27/04/2017.
leen abuafifeh
Mind Map by leen abuafifeh, updated more than 1 year ago
leen abuafifeh
Created by leen abuafifeh about 7 years ago
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I always feel tired
  1. diagnosed with
    1. Fe deficiency anemia
      1. anemia
        1. Normocytic
          1. increased destruction (hemolytic anemia)
            1. Hereditary spehrocytosis
            2. Sickle cell anemia
              1. Glucose-6-phosphate dehydrogenase (G6PD) deficiency
                1. Paroxysmal Nocturnal Hemoglobeinuria
                2. MCV: >100um3
                  1. Macrocytic
                    1. Megaloblastic anemia
                      1. VB 12 deficiency
                        1. symptoms of VB12 DEF
                          1. Nerve damage.
                            1. Neurological problems
                              1. Nausea and vomiting
                                1. enlarged liver
                                  1. smooth, beefy red tongue
                                  2. CAUSES
                                    1. vegan
                                      1. Impaired absorption
                                        1. Intrinsic factor deficiency (prenicious anemia- gastrectomy
                                          1. Malabsorption diseases (pancreatic insufficiency)
                                            1. Diffuse intestinal disease (lymphoma-Crohn’s
                                              1. Competitive parasitic uptake (tape worm infestation)
                                          2. folate deficiency
                                            1. Increased homocysteine level
                                              1. Normal mehylmalonic acid
                                                1. CAUSES
                                                  1. Dietary deficiency (alcohol-elderly)
                                                    1. Increased demand pregnancy- cancer patients
                                                  2. Impaired DNA synthesis
                                                    1. Ineffective erythropoiesis
                                                  3. Non-megaloblastic anemia
                                                    1. Alcoholism
                                                      1. Drugs (Ex- 5 FU)
                                                        1. Liver disease
                                                    2. SYMPTOMPS OF ANEMIA
                                                      1. MCV: <80
                                                        1. Microcytic
                                                          1. Anemia of chronic disease
                                                            1. TB
                                                              1. Rheumatoid arthritis
                                                                1. Malignancy
                                                                  1. Chronic alcoholism
                                                                    1. Iron is trapped in BM macrophages
                                                                      1. HEPCIDIN prevents the release of iron from BM
                                                                        1. decrese EPO production
                                                                          1. Increase in BM iron stores
                                                                    2. Sideroblastic
                                                                      1. Chronic alcoholism
                                                                        1. VB6 deficiency
                                                                          1. Lead poisoning
                                                                            1. INH therapy
                                                                              1. Hereditary types (x- linked)
                                                                                1. Free iron accumulates inside the mitochondria (Iron loaded mitochondria in the bone marrow erythroblasts)
                                                                                  1. RING SIDEROBLASTS
                                                                            2. Risk factors
                                                                              1. Women
                                                                                1. Infants and children
                                                                                  1. Vegetarians
                                                                                    1. Frequent blood donors
                                                                                    2. Complications
                                                                                      1. Heart problems
                                                                                        1. Problems during pregnancy
                                                                                          1. Growth problems
                                                                                          2. Treatment
                                                                                            1. Oral or parenteral iron preparations
                                                                                              1. pyridoxine
                                                                                                1. Hydroxyurea
                                                                                                  1. Pentoxifylline
                                                                                                  2. RBC
                                                                                                    1. HB
                                                                                                      1. Transport of O2 from lungs to tissues &CO2 and H+ from tissues to the lungs for excretion
                                                                                                        1. HEME
                                                                                                          1. porphyrin ring with central iron
                                                                                                            1. . Iron is the site of attachment with O2.
                                                                                                              1. 4 heme groups
                                                                                                                1. 4 O2 molecules
                                                                                                                2. Iron
                                                                                                                  1. immune system healthy
                                                                                                                    1. produce the connective tissue
                                                                                                                      1. STORED
                                                                                                                        1. Ferritin
                                                                                                                          1. TRASPORTED
                                                                                                                            1. Transferrin
                                                                                                                3. GLOBIN
                                                                                                          2. Microcytic hypochromic
                                                                                                            1. C/P
                                                                                                              1. General features of anemia
                                                                                                                1. Epithelial atrophy- Plummer Vinson syndrome
                                                                                                                  1. Koilonichia
                                                                                                                    1. Pica
                                                                                                                  2. causes
                                                                                                                    1. increased loss
                                                                                                                      1. dietary deficiency

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