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8840210
leukemia
Description
Mind Map on leukemia, created by mahmoud eladl on 08/05/2017.
Mind Map by
mahmoud eladl
, updated more than 1 year ago
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Created by
mahmoud eladl
over 7 years ago
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Resource summary
leukemia
occurs to
White blood cells
Morphology: Irregular- Multilobular nuclei
Life span: 4-30 days
Percentage in blood: 1%
Function: Immunity against microorganisms
Types
granulocytes
Basophil
Eosinophil
Neutrophil
Agranulocytes
Lymphocytes
T Lymphocytes
B Lymphocytes
Plasma cells
NK cells
Monocyte
Macrophages
Content: Antibodies and granules
count
abnormalities
leukocytosis
causes
Bacterial infections
Corticosteroids
Myocardial infarction
Viral infections
Autoimmune
Malignancy
leukocytopenia
definition: Uncontrolled production of WBCs mainly caused by cancerous mutation.
Risk factors
Tobacco smoke
Radiation exposure
Chemotherapy and radiation therapy
Family history
congenital disorder
Drugs and toxins
Types
Acute Leukemia
AML
ALL
Chronic Leukemia
CLL
Chronic Myeloid leukemia
definition: cancerous increased numbers of cells belonging to the myeloid cell
Complications
Pain
Fatigue
Enlarged Spleen
Excess bleeding
Infention
Pathogenesis
Ph chromosome : t(9;22) Translocation
oncogene ( BCR-ABL )<
Phases
1_Chronic phase
2_ Accelerated phase
3_ Blast phase
Risk Factors
Radiation
Age
Gender
Clinical Manifestation
Fatigue
Weight loss
Excessive sweating
Abdominal fullness
Bleeding episodes
Abdominal pain
treatment
TKI
chemotherapy
HSCT
complications
-headache -nausea -pain -GVHD
Investigations
Bone marrow tests
CBC
Blood chemistry
PCR
FISH
karyotype
Imaging tests
blood smear
Prognosis
all patient treated since 2001 are alive until now and no accurate number for the years to live
Sign & Symptoms
Fever and Night sweats -Tiredness -Headaches -Joint or bone pain -Getting infections often -Losing weight and appetite
-Pallor -Bone tenderness -Retinal hemorrhage -Hepatosplenomegaly -Gingival involvement (AML) -Choloroma -Swollen abdomen -Swollen lymphnodes
Complications
Infections
Death
Richter Transformation
Blood Problems
Kaposis sarcoma
Lung cancer
Autoimmune hemolytic anemia
splenomegaly
causes
Infections
Hemolytic anemias
ITP
Leukemia
Lymphoma
Myeloproliferative disorders
Sarcoma
diagnosed
Blood test
Bone marrow biopsy
Lymph node biopsy
Lumbar puncture
Flow cytometry
Cytogenetic and FISH
Immunophenotyping
Media attachments
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