8844181
Description
Mind Map by Dana Alobadily, updated more than 1 year ago
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Created by Dana Alobadily
almost 8 years ago
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Muhammed spleen is
palpable
- Differences between
- leukocytosis: increase in the
number of WBCs .' non
neoplastic"
- Neutrophilic leukocytosis:
(count >7000cells/ mm3)
- Bacterial infections- Corticosteroids
(inhinit margination) -Myocardial
infarction
- Bacterial infections- Corticosteroids
(inhinit margination) -Myocardial
infarction
- Lymphocytosis: (Absolute
count >4000cells/ mm3
- Viral infections (infectious
mononucleosis) -Drugs (phynetoin)
- Viral infections (infectious
mononucleosis) -Drugs (phynetoin)
- Eosiniophilia
- Type I hypersensitivity reaction
(bronchial asthma- reaction to
penicillin)- Helminthic infection
- Type I hypersensitivity reaction
(bronchial asthma- reaction to
penicillin)- Helminthic infection
- Monocytosis
- Chronic infections : TB
- Chronic infections : TB
- Neutrophilic leukocytosis:
(count >7000cells/ mm3)
- leukomoid reaction:This is a
reactive and excessive
leukocytosis."mimic leukemia"
- WBC counts up to 15 - 100,000/mm3
- Shift to the left (immature WBCs)
- Signs of activation Doehle bodies, toxic
granulations (Differs the condition from CML)
- toxic granulation
- Doehle bodies
- NAP scores high (Differs the
condition from CML)
- MPO negative (Myeloperoxidase) to
differ from CML
- toxic granulation
- WBC counts up to 15 - 100,000/mm3
- leukocytosis: increase in the
number of WBCs .' non
neoplastic"
- Hematological neoplasms
- Hematological History Taking
- Hematology Physical
Examination
- Chronic Myeloid Leukemia
- phases
- confirming tests
- FISH
- PCR
- Karyotyping
- Bone Marrow Biopsy in
accelerated phase
- FISH
- presence of Philadelphia
chromosome 22 due to
translocation
- Fusion of 2 genes: BCR (or chromosome
22) and ABL1 (on chromosome 9),
resulting in BCR-ABL1 fusion gene
- Fusion of 2 genes: BCR (or chromosome
22) and ABL1 (on chromosome 9),
resulting in BCR-ABL1 fusion gene
- Management
- tyrosine kinase inhibitor
- imatinib
- inhibit TK enzyme
- inhibit TK enzyme
- imatinib
- Hematopoietic stem cell
transplantation
- tyrosine kinase inhibitor
- clinical presentation
- Asymptomatic
- abdominal fullness due to
splenomegaly
- weight loss - fatigue
- Asymptomatic
- phases
- Investigations
- CBC
- Blood film
- Blood film at 1000X magnification
shows a promyelocyte, an
eosinophil, and 3 basophils.
- Blood film at 400X magnification
demonstrates leukocytosis with the presence
of precursor cells of the myeloid lineage. In
addition, basophilia, eosinophilia, and
thrombocytosis can be seen.
- Blood film at 1000X magnification
shows a promyelocyte, an
eosinophil, and 3 basophils.
- CBC
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