5. Protecting Groups

Descrição

Chemistry FlashCards sobre 5. Protecting Groups, criado por John Rivada em 20-04-2019.
John Rivada
FlashCards por John Rivada, atualizado more than 1 year ago
John Rivada
Criado por John Rivada mais de 5 anos atrás
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Resumo de Recurso

Questão Responda
Properties for kinetic product -Forms faster -Rx usually short -Low temperature -Reversible under thermodynamic conditions
Properties for thermodynamic product -Forms more slowly but more stable -Rx is long -High temperature -Irreversible
Mechanism?
Mechanism?
How do you protect the amine group of an amino acid? Cbz Benzyl chloroformate
How do you protect the amine group of an amino acid? Boc (t-BuOCO) Deprotect with H+ and H2O
How do you protect the amine group of an amino acid? FMoc-Cl, base Deprotect with amine base (e.g. pyridine)
How to make t-butyl ester **
How do you protect the carboxylic acid group of an amino acid? ROH, H+ Deprotect with -OH (LiOH, NaOH)
How do you protect the carboxylic acid group of an amino acid? isobutene, H+ Deprotect with strong acid
How do you protect the carboxylic acid group of an amino acid? PHCH2OH and H+ or PhCH2Br and base Deprotect with H2 + cat. Pd/C or -OH
Slide 27 **
Slide 29 **
Slide 30 **
Solid phase peptide synthesis 88

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