28860659
Descrição
FlashCards por Ruchira Datta, atualizado more than 1 year ago
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Criado por Ruchira Datta
quase 4 anos atrás
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| Questão | Responda |
| physical barriers in innate immunity solid | skin nose hairs mucous membranes (respiratory & GI) |
| physical barriers in innate immunity liquid | tears saliva mucus |
| physical barriers in innate immunity molecules | defensins lysozyme stomach acid |
| lysozyme | found in tears & mucus digests bacterial cell walls |
| physiological responses in innate immunity | sneezing coughing release of soluble factors in inflammatory response |
| soluble factors in inflammatory response | cytokines kinins vasoactive amines defensins |
| cytokines | proteins binding receptor on target cell membrane alter target cell behavior alter body temperature (fever) fatigue & aches target endothelial cells & cells in blood |
| kinins | trigger changes in blood vessels trigger release of neuropeptides activate sensory nerves (pain) |
| defensins | on skin & mucosal surfaces tongue & cornea punch holes in bacterial cell membranes |
| bradykinin | activates sensory nerves causing pain dilates blood vessels causing redness & heat increases vascular permeability causing swelling/edema |
| complement | directly kills pathogens activates & recruits white blood cells causes tissue cells to release cytokines |
| pro-inflammatory triad | IL-1, IL-6, TNF-alpha systemic inflammatory response |
| extravasation | cytokines make white blood cells sticky white blood cells stick lightly to vessel walls white blood cells roll along endothelial cells leak near infection/injury site white cells move into inflamed area |
| three classes of cytokines | chemokines interleukins (ILs) & interferons (IFNs) colony stimulating factors (CSFs) |
| chemokines | small 1k-dalton conserved cystein patterns per subgroup stick to endothelial cells making gradient recruited cells undergo chemotaxis |
| chemotaxis | moving along chemokine gradient |
| ILs & IFNs | interleukins & interferons 10-30 Kd induce differentiation/proliferation of immature cells recruit/activate mature effector cells interferon from infected cells makes neighbors antiviral |
| inflammatory action on hypothalamus | releases prostaglandin increases body temperature |
| inflammatory action on liver | production of complement components upregulates glucose production |
| inflammatory action on bone marrow | produces replacement white cells if chronic/relapsing, triggers bone resorption and over time, osteoporosis |
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