3825960
| Questão | Responda |
| PHENOXYBENZAMINE Acts as an irreversible alpha 1 antagonist has an affinity for the receptor only use irreversible antagonist for chronic conditions and need sustained effect used in reynauds disease (not preferred anymore) dont want to used in young women because it will cause genetic problems in baby used in frostbite for peripheral dilation Biggest thing is it covalently binds to receptor used in bph for men over 50 | |
| PRAZOSIN 1st selective alpha 1 antagonist with widespread clinical use reduce bp does cause peripheral vasodilation dizziness when quickly standing (orthostatic hypotension) very bad for old people with weak bones very bad for | |
| TERAZOSIN 1/2 life is 12 hours DOA = 18 hours BID dosing People with BPH could sleep through the night with longer DOA | |
| DOXAZOSIN 1/2 life is 22 hours DOA=36 hours QD dosing Anti-HTN and BPH treatment | |
| ALFLUZOSIN Not effective for reducing BP Increased specificity for sphincter (alpha 1a) Orthostatic Hypotension (Not good for old people) 1/2 life is 10hrs | |
| TAMSULOSIN Used for BPH Highly selective for alpha 1A Not used for Anti HTN High enough dose will cause decrease in BP 0.4 mg QD HS with DOA of 15 hours | |
| SILODOSIN Alpha 1a receptors Were looking at it as a male contraceptive | |
| PHENTOLAMINE Reversible alpha antagonist Limited treatment in frostbite, dilates arterioles Given by injection |
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