440292
Descrição
FlashCards por gina_evans0312, atualizado more than 1 year ago
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Criado por gina_evans0312
mais de 10 anos atrás
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| Questão | Responda |
| Effects of Single Base Changes | Can vary- can be massive, small, or makes no difference at all |
| GAG --> GUG in Sickle Cell Anemia | Glutamate --> Valine |
| Mutation in S.C.A | Causes loss of polar protein at position 6 |
| Promotion of non-covalent polymerisation in S.C.A | Is what causes Hb agglutination and sickle shaped cells |
| S.I of Whale & Human Hb | 17% - but same function |
| Gene loss in bacteria | Bacteria can excise non-functioning DNA |
| Gene inactivation | Where mutations effect promoter regions |
| Small Insertions/Deletion | Allows specificity for different substrates- leads to related protein types |
| Whole domains can be inserted as long as... | the core remains undamaged and able to perform it's function |
| Cause of Paralogues | Gene Duplication |
| Limit of replication | Whole genomes/chromosomes |
| Movement of replicated genes | To other chromosomes or fusion with other genes |
| Gene Rearrangement | Incorrect duplication can lead to rearrangement of domains/fusion proteins |
| % of domain pairs in the same order | 90- gene rearrangement is difficult to successfully |
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