Secondary (invivo) screening

Descrição

The invivo preparations and the tests carried on them
Ayman Barghout
FlashCards por Ayman Barghout, atualizado more than 1 year ago
Ayman Barghout
Criado por Ayman Barghout mais de 8 anos atrás
8
0

Resumo de Recurso

Questão Responda
In-vivo preparations 1. Anesthetized cat blood pressure. 2. Cat nictitating membrane
Anesthetized cat blood pressure preparation Animals are cannulated at 3 sites: 1. Tracheal cannulation. 2. Femoral vein cannulation. 3. Femoral artery cannulation
1. Tracheal cannulation Polyethylene cannula is introduced into the trachea, cannula is connected to respirometer (artificial ventilator) to overcome respiratory pralysis produced by skeletal muscles relaxants.
2. Femoral vein cannulation Through a small cut in the vein connected to a syringe for IV adminstration of drugs
3. Femoral artery cannulation The femoral artery is connected to a blood pressure transducer for blood pressure measurement which converts blood pressure to electronic signals which are recorded on a multi-channel system
Tetrad system 1. Electrical vagal stimulation. 2. IV administration of acetylcholine. 3. Bilateral Carotid Occlusion (OCB). 4. IV administration of epinephrine or norepinephrine.
Vagus nerve The parasympathetic nerve supplying the heart & GIT.
Vagus nerve origin It originates from 2 nuclei in the meddula oblongata 1. Dorsal motor nucleus of vagus (DMV) 2. Nucleus ambiguous (NA)
1. Electrical vagal stimulation 1. The neck area is opened and one of the two vagi is dissected. 2. Vagus nerve is stimulated electrically (preganglionic stimulation)
Effect of electrical vagal stimulation 1. Release of endogenous Acetylcholine which affects \[M_2\] receptor in heart. 2. Bradycardia → decreased cardiac output → hypotension.

Semelhante

Ch. 2 Ancient Mesopotamia & Egypt
msandovalbarrios
PHARMACOLOGY BLOCK 1- basic intro
wallacejr@hotmail.co
PUBLIC HEALTH
Zinab Keshk
Exam 1 Medications
tera_alise
Introduction to pharmacology
Ifeoma Ezepue
Drug receptor interactions
Ifeoma Ezepue
Pharmacology II-III
Gwen Paparone
Pharmacology Chap 10 & 11
Robin Gatson
Monoamine pharmacology -Antidepressant drugs - Dr. Emma Robinson
Anna mph
pharmacology chapter 8 and 20
Alannah Mendoza